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Literature summary for 1.14.14.166 extracted from

  • Abedini, D.; Monfared, S.R.; Abbasi, A.
    The effects of promoter variations of the N-methylcanadine 1-hydroxylase (CYP82Y1) gene on the noscapine production in opium poppy (2018), Sci. Rep., 8, 4973 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.166

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 Papaver bracteatum the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine (S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 Papaver somniferum the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine (S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Papaver bracteatum
-
-
-
Papaver somniferum I3PLR1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Papaver somniferum
-
leaf expression is lower than in Papaver somniferum Papaver bracteatum
-
seed
-
 Papaver somniferum
-
stem
-
 Papaver somniferum
-
stem expression is lower than in Papaver somniferum Papaver bracteatum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
-
 Papaver bracteatum (S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
-
 Papaver somniferum (S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine Papaver bracteatum (S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine Papaver somniferum (S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP82Y1
-
 Papaver somniferum
N-methylcanadine 1-hydroxylase
-
 Papaver bracteatum
N-methylcanadine 1-hydroxylase
-
 Papaver somniferum
PbCYP82Y1
-
 Papaver bracteatum

Expression

Organism Comment Expression
Papaver somniferum an SSR (Simple Sequence Repeats) is embedded in the promoter region of the CYP82Y1 gene. Quantitative PCR shows that a variation in the motif repeat number (either a decrease or increase) down-regulates the expression of the CYP82Y1 gene down

General Information

General Information Comment Organism
metabolism the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine Papaver bracteatum
metabolism the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine Papaver somniferum