Literature summary for 1.14.14.166 extracted from

Li, Y.; Li, S.; Thodey, K.; Trenchard, I.; Cravens, A.; Smolke, C.
Complete biosynthesis of noscapine and halogenated alkaloids in yeast (2018), Proc. Natl. Acad. Sci. USA, 115, E3922-E3931 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Saccharomyces cerevisiae	Papaver somniferum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2	Papaver somniferum	the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine. The pathway for biosynthesis of noscapine, a potential anticancer compound, from canadine is a 10-gene cluster	(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Papaver somniferum	I3PLR1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2	-	Papaver somniferum	(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2	the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine. The pathway for biosynthesis of noscapine, a potential anticancer compound, from canadine is a 10-gene cluster	Papaver somniferum	(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
1-hydroxy-N-methylcanadine synthase	-	Papaver somniferum
CYP82Y1	-	Papaver somniferum

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome P-450	heme-thiolate enzyme	Papaver somniferum

General Information

General Information	Comment	Organism
metabolism	the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine	Papaver somniferum

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Release 2023.1 (January 2023)