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Literature summary for 1.14.14.165 extracted from
- In planta biocatalysis screen of P450s identifies 8-methoxypsoralen as a substrate for the CYP82C subfamily, yielding original chemical structures (2008), Chem. Biol., 15, 149-156 .
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | the therapeutic compound 8-methoxypsoralen is hydroxylated by plants overexpressing CYP82C2 or CYP82C4, forming 5-hydroxy-8-methoxypsoralen | Arabidopsis thaliana |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | O49394 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seedling | - |
Arabidopsis thaliana | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 8-methoxypsoralen + [reduced NADPH-hemoprotein reductase] + O2 | - |
Arabidopsis thaliana | 5-hydroxy-8-methoxypsoralen + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP82C2 | - |
Arabidopsis thaliana |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P-450 | a cytochrome P-450 (heme thiolate) enzyme | Arabidopsis thaliana |
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