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Literature summary for 1.14.14.161 extracted from

  • Miettinen, K.; Dong, L.; Navrot, N.; Schneider, T.; Burlat, V.; Pollier, J.; Woittiez, L.; Van Der Krol, S.; Lugan, R.; Ilc, T.; Verpoorte, R.; Oksman-Caldentey, K.; Martinoia, E.; Bouwmeester, H.; Goossens, A.; Memelink, J.; Werck-Reichhart, D.
    The seco-iridoid pathway from Catharanthus roseus (2014), Nat. Commun., 5, 3606 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.161

Cloned(Commentary)

Cloned (Comment) Organism
expression in in Saccharomyces cerevisiae Catharanthus roseus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum assosiated with Catharanthus roseus 5783
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 Catharanthus roseus the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Catharanthus roseus W8JIS5
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-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis high activity Catharanthus roseus
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mesophyll low activity Catharanthus roseus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction Catharanthus roseus 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
(+)-cis,trans-nepetalactol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus 7-deoxyloganetic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
7-deoxyloganetic alcohol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus iridotrial + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
iridotrial + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus 7-deoxyloganetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP76A26
-
 Catharanthus roseus
iridoid oxidase misleading Catharanthus roseus

Cofactor

Cofactor Comment Organism Structure
cytochrome P-450 a cytochrome P-450 (heme thiolate) enzyme Catharanthus roseus

General Information

General Information Comment Organism
metabolism the enzyme catalyses three successive reactions in the seco-iridoid pathway leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus