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Literature summary for 1.14.14.160 extracted from

  • Mao, H.; Liu, J.; Ren, F.; Peters, R.J.; Wang, Q.
    Characterization of CYP71Z18 indicates a role in maize zealexin biosynthesis (2016), Phytochemistry, 121, 4-10 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
CYP71Z18 is expressed in the C41 (DE3) OverExpress strain of Escherichia coli (Lucigen) Zea mays

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-beta-macrocarpene + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] Zea mays the enzyme sequentially oxidizes (S)-beta-macrocarpene via alcohol and aldehyde intermediates to form zealexin A1, a maize phytoalexin that provides biochemical protection against fungal infection, overall reaction zealexin A1 + 4 H2O + 3 [oxidized NADPH-hemoprotein reductase]
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Organism

Organism UniProt Comment Textmining
Zea mays B4FVP3
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + [reduced NADPH-hemoprotein reductase] the enzyme sequentially oxidizes(S)-beta-macrocarpene via alcohol and aldehyde intermediates to form zealexin A1 Zea mays zealexin A1 + H2O + [oxidized NADPH-hemoprotein reductase]
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?
(S)-beta-macrocarpene + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] the enzyme sequentially oxidizes (S)-beta-macrocarpene via alcohol and aldehyde intermediates to form zealexin A1, a maize phytoalexin that provides biochemical protection against fungal infection, overall reaction Zea mays zealexin A1 + 4 H2O + 3 [oxidized NADPH-hemoprotein reductase]
-
?
(S)-beta-macrocarpene + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] the enzyme sequentially oxidizes(S)-beta-macrocarpene via alcohol and aldehyde intermediates to form zealexin A1, overall reaction Zea mays zealexin A1 + 4 H2O + 3 [oxidized NADPH-hemoprotein reductase]
-
?
(S)-beta-macrocarpene + O2 + [reduced NADPH-hemoprotein reductase] the enzyme sequentially oxidizes(S)-beta-macrocarpene via alcohol and aldehyde intermediates to form zealexin A1 Zea mays [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H2O + [oxidized NADPH-hemoprotein reductase]
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?
[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl] methanol + O2 + [reduced NADPH-hemoprotein reductase] the enzyme sequentially oxidizes(S)-beta-macrocarpene via alcohol and aldehyde intermediates to form zealexin A1 Zea mays (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + 2 H2O + [oxidized NADPH-hemoprotein reductase]
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?

Synonyms

Synonyms Comment Organism
CYP71Z18
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Zea mays

Cofactor

Cofactor Comment Organism Structure
cytochrome P-450 a cytochrome P-450 (heme thiolate) enzyme Zea mays

Expression

Organism Comment Expression
Zea mays transcription is strongly induced by fungal infection up

General Information

General Information Comment Organism
metabolism the enzyme sequentially oxidizes (S)-beta-macrocarpene via alcohol and aldehyde intermediates to form zealexin A1, a maize phytoalexin that provides biochemical protection against fungal infection Zea mays
physiological function the enzyme sequentially oxidizes (S)-beta-macrocarpene via alcohol and aldehyde intermediates to form zealexin A1, a maize phytoalexin that provides biochemical protection against fungal infection Zea mays