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Literature summary for 1.14.14.154 extracted from
- Expression and homology modelling of sterol 14alpha-demethylase of Magnaporthe grisea and its interaction with azoles (2009), Pest Manag. Sci., 65, 260-265.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | non-conservative Phe497 and Phe220 of CYP51 may be key residues for design of potent specific fungicides for CYP51 | Pyricularia grisea |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| full-length and truncated CYP51 fragments cloned into vector pET30 and expressed in Escherichia coli strain BL21 (DE3) pLysS | Pyricularia grisea |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diniconazole | is the most sensitive fungicide for CYP51, has a stronger affinity for CYP51 than the other fungicides | Pyricularia grisea |  |
| additional information | affinity of the azoles for CYP51 is positively correlated with their hydrophobicity. Amino acid residues Tyr112, Phe120, Phe220, His308 and Phe497 of CYP51, forming a large hydrophobic cavity, are the key residues interacting with azole fungicides | Pyricularia grisea | |
| tebuconazole | - |
Pyricularia grisea | |
| triadimefon | is the less sensitive fungicide for CYP51, affinity for CYP51 is the weakest | Pyricularia grisea | |
| triadimenol | hydrophobicity of triadimenol is reduced by the shortening of the carbon chain and the addition of a polar oxygen atom in comparison with tebuconazole, which may be the cause of the decrease in the affinity of triadimenol compared with tebuconazole | Pyricularia grisea | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Iron | - |
Pyricularia grisea | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 51000 | - |
sequence analysis, truncated CYP51 | Pyricularia grisea |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pyricularia grisea | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP51 | - |
Pyricularia grisea |
| sterol 14alpha-demethylase | - |
Pyricularia grisea |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P450 | - |
Pyricularia grisea |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | truncated CYP51 is successfully expressed in Escherichia coli, whereas the full-length CYP51 is not | Pyricularia grisea |
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Release 2023.1 (January 2023)
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