Cloned (Comment) | Organism |
---|---|
subcloned into the pCW vector (Nde I/Hind III cloning sites) and expressed in Escherichia coli | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-phenyl-N-pyridin-4-ylbutanamide | - |
Trypanosoma cruzi | |
2-[1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]-N-(1-pyridin-4-ylethyl)acetamide | - |
Trypanosoma cruzi | |
2-[1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]-N-(2-phenylpropyl)acetamide | most potent inhibitor, antiparasitic activities at concentrations less than 0.01 mM | Trypanosoma cruzi | |
2-[1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]-N-(2-pyridin-3-ylethyl)acetamide | - |
Trypanosoma cruzi | |
2-[1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]-N-(pyridin-2-ylmethyl)acetamide | - |
Trypanosoma cruzi | |
2-[1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]-N-(pyridin-4-ylmethyl)acetamide | - |
Trypanosoma cruzi | |
2-[1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]-N-pyridin-2-ylacetamide | - |
Trypanosoma cruzi | |
2-[1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]-N-pyridin-3-ylacetamide | - |
Trypanosoma cruzi | |
2-[1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]-N-pyrimidin-2-ylacetamide | - |
Trypanosoma cruzi | |
2-[1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]-N-[(6-chloropyridin-3-yl)methyl]acetamide | - |
Trypanosoma cruzi | |
2-[1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]-N-[2-(3-chlorophenyl)ethyl]acetamide | most potent inhibitor, antiparasitic activities at concentrations less than 0.01 mM | Trypanosoma cruzi | |
2-[1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide | - |
Trypanosoma cruzi | |
3-(2-furyl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole | most potent inhibitor | Trypanosoma cruzi | |
3-benzyl-1-pyridin-4-ylpyrrolidine-2,5-dione | - |
Trypanosoma cruzi | |
3-methyl-4-nitro-N-pyridin-4-ylbenzamide | - |
Trypanosoma cruzi | |
3-oxo-N-pyridin-4-yl-3H-benzo[f]chromene-2-carboxamide | - |
Trypanosoma cruzi | |
3-thien-2-yl-5,6-dihydroimidazo[2,1-b][1,3]thiazole | - |
Trypanosoma cruzi | |
N-pyridin-4-yl-9H-xanthene-9-carboxamide | strongest binding compound | Trypanosoma cruzi | |
Nalpha-[(4-methylcyclohexyl)carbonyl]-N-pyridin-4-yltryptophanamide | strongest binding compound | Trypanosoma cruzi |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | - |
Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Trypanosoma cruzi |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | - |
Trypanosoma cruzi | - |
trypomastigote | - |
Trypanosoma cruzi | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | preferred substrate | Trypanosoma cruzi | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Trypanosoma cruzi | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP51 | - |
Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | - |
Trypanosoma cruzi |