Literature summary for 1.14.14.154 extracted from

Krishnan-Natesan, S.; Chandrasekar, P.H.; Alangaden, G.J.; Manavathu, E.K.
Molecular characterisation of cyp51A and cyp51B genes coding for P450 14alpha-lanosterol demethylases A (CYP51Ap) and B (CYP51Bp) from voriconazole-resistant laboratory isolates of Aspergillus flavus (2008), Int. J. Antimicrob. Agents, 32, 519-524.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Aspergillus flavus

Protein Variants

Protein Variants	Comment	Organism
H399P/D411N	CYP51Ap mutant of voriconazole-resistant clinical isolate, shows higher minimum inhibitory concentration of voriconazole compared with the drug-susceptible parent	Aspergillus flavus
K197N	CYP51Ap mutant of voriconazole-resistant clinical isolate, shows higher minimum inhibitory concentration of voriconazole compared with the drug-susceptible parent	Aspergillus flavus
K197N/D282E/M288L	CYP51Ap mutant of voriconazole-resistant clinical isolate, shows higher minimum inhibitory concentration of voriconazole compared with the drug-susceptible parent	Aspergillus flavus
T454P/T486P	CYP51Ap mutant of voriconazole-resistant clinical isolate, shows higher minimum inhibitory concentration of voriconazole compared with the drug-susceptible parent	Aspergillus flavus
Y132N/T469S	CYP51Ap mutant of voriconazole-resistant clinical isolate, shows higher minimum inhibitory concentration of voriconazole compared with the drug-susceptible parent	Aspergillus flavus

Inhibitors

Inhibitors	Comment	Organism	Structure
Amphotericin B	-	Aspergillus flavus
itraconazole	-	Aspergillus flavus
posaconazole	-	Aspergillus flavus
ravuconazole	-	Aspergillus flavus
voriconazole	-	Aspergillus flavus

Organism

Organism	UniProt	Comment	Textmining
Aspergillus flavus	-	voriconazole-resistant clinical isolates and voriconazole-susceptible parent strain X26728	-

Synonyms

Synonyms	Comment	Organism
CYP51Ap	-	Aspergillus flavus
CYP51Bp	-	Aspergillus flavus
P450 14alpha-lanosterol demethylases A	-	Aspergillus flavus
P450 14alpha-lanosterol demethylases B	-	Aspergillus flavus

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Release 2023.1 (January 2023)