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Literature summary for 1.14.14.154 extracted from
- Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (2009), Eur. J. Med. Chem., 44, 1913-1920.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2,4-dichlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida parapsilosis |  |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2,4-dichlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2,4-dichlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2,4-dichlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida albicans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida parapsilosis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida albicans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida parapsilosis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida albicans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida parapsilosis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida albicans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida parapsilosis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida albicans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida parapsilosis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida albicans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida parapsilosis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida albicans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida parapsilosis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida albicans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida parapsilosis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida albicans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida albicans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida parapsilosis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida albicans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida parapsilosis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida albicans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida parapsilosis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol | exhibits higher activity than fluconazole | Candida albicans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol | exhibits higher activity than fluconazole | Candida parapsilosis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol | exhibits higher activity than fluconazole | Candida tropicalis | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| 3-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Candida albicans | |
| 3-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate | - |
Candida tropicalis | |
| 4-(propoxycarbonyl)-phenyl-[4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]amino)methyl)]benzoate | exhibits higher activity than fluconazole | Candida parapsilosis | |
| 4-(propoxycarbonyl)-phenyl-[4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]amino)methyl)]benzoate | - |
Candida tropicalis | |
| 4-chlorophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits activity than fluconazole | Nannizzia gypsea | |
| 4-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Candida albicans | |
| 4-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits activity than fluconazole | Nannizzia gypsea | |
| 4-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| Amphotericin B | - |
Candida albicans | |
| Amphotericin B | - |
Candida parapsilosis | |
| Amphotericin B | - |
Candida tropicalis | |
| Amphotericin B | - |
Cryptococcus neoformans | |
| Amphotericin B | - |
Nannizzia gypsea | |
| Amphotericin B | - |
Pichia kudriavzevii | |
| Amphotericin B | - |
Trichophyton rubrum | |
| butyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Candida albicans | |
| butyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| butyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| ethyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Candida albicans | |
| ethyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | - |
Candida tropicalis | |
| ethyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits activity than fluconazole | Nannizzia gypsea | |
| ethyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| ethyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| fluconazole | binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group | Candida albicans | |
| fluconazole | binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group | Candida parapsilosis | |
| fluconazole | binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group | Candida tropicalis | |
| fluconazole | binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group | Cryptococcus neoformans | |
| fluconazole | binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group | Nannizzia gypsea | |
| fluconazole | binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group | Pichia kudriavzevii | |
| fluconazole | binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group | Trichophyton rubrum | |
| isobutyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Candida parapsilosis | |
| isobutyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| isobutyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| isobutyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| isopropyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Candida albicans | |
| isopropyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| isopropyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| isopropyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| itraconazole | - |
Aspergillus fumigatus | |
| itraconazole | - |
Candida albicans | |
| itraconazole | - |
Candida parapsilosis | |
| itraconazole | - |
Candida tropicalis | |
| itraconazole | - |
Cryptococcus neoformans | |
| itraconazole | - |
Nannizzia gypsea | |
| itraconazole | - |
Pichia kudriavzevii | |
| itraconazole | - |
Trichophyton rubrum | |
| ketoconazole | - |
Aspergillus fumigatus | |
| ketoconazole | - |
Candida albicans | |
| ketoconazole | - |
Candida parapsilosis | |
| ketoconazole | - |
Candida tropicalis | |
| ketoconazole | - |
Cryptococcus neoformans | |
| ketoconazole | - |
Nannizzia gypsea | |
| ketoconazole | - |
Pichia kudriavzevii | |
| ketoconazole | - |
Trichophyton rubrum | |
| methyl-2-[4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoyloxy]-benzoate | exhibits higher activity than fluconazole | Candida albicans | |
| methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Candida albicans | |
| methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Candida parapsilosis | |
| methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | - |
Candida tropicalis | |
| methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Cryptococcus neoformans | |
| methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Nannizzia gypsea | |
| methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| additional information | is not inhibited by fluconazole, amphotericin B, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2,4-dichlorobenzyl)-amino]-2-propanol, methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, ethyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, isopropyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, isopropyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, isobutyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, pentyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, phenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, 3-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate, 4-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate, 4-chlorophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate, methyl-2-[4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoyloxy]-benzoate or 4-(propoxycarbonyl)-phenyl-[4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]amino)methyl)]benzoate | Aspergillus fumigatus | |
| additional information | inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft | Candida albicans | |
| additional information | inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft | Candida parapsilosis | |
| additional information | inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft | Candida tropicalis | |
| additional information | inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft | Cryptococcus neoformans | |
| additional information | inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft | Nannizzia gypsea | |
| additional information | inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft | Pichia kudriavzevii | |
| pentyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| pentyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Trichophyton rubrum | |
| phenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate | exhibits higher activity than fluconazole | Pichia kudriavzevii | |
| terbinafine | - |
Aspergillus fumigatus | |
| terbinafine | - |
Candida albicans | |
| terbinafine | - |
Candida parapsilosis | |
| terbinafine | - |
Candida tropicalis | |
| terbinafine | - |
Cryptococcus neoformans | |
| terbinafine | - |
Nannizzia gypsea | |
| terbinafine | - |
Pichia kudriavzevii | |
| terbinafine | - |
Trichophyton rubrum | |
| voriconazole | - |
Aspergillus fumigatus | |
| voriconazole | - |
Candida albicans | |
| voriconazole | - |
Candida parapsilosis | |
| voriconazole | - |
Candida tropicalis | |
| voriconazole | - |
Cryptococcus neoformans | |
| voriconazole | - |
Nannizzia gypsea | |
| voriconazole | - |
Pichia kudriavzevii | |
| voriconazole | - |
Trichophyton rubrum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus fumigatus | - |
- |
- |
| Candida albicans | - |
strain ATCC7661 | - |
| Candida albicans ATCC 7661 | - |
strain ATCC7661 | - |
| Candida parapsilosis | - |
- |
- |
| Candida tropicalis | - |
- |
- |
| Cryptococcus neoformans | - |
- |
- |
| Nannizzia gypsea | - |
- |
- |
| Pichia kudriavzevii | - |
- |
- |
| Trichophyton rubrum | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP51 | - |
Pichia kudriavzevii |
| CYP51 | - |
Candida albicans |
| CYP51 | - |
Candida tropicalis |
| CYP51 | - |
Cryptococcus neoformans |
| CYP51 | - |
Candida parapsilosis |
| CYP51 | - |
Aspergillus fumigatus |
| CYP51 | - |
Trichophyton rubrum |
| CYP51 | - |
Nannizzia gypsea |
| cytochrome P450 14alpha-demethylase | - |
Pichia kudriavzevii |
| cytochrome P450 14alpha-demethylase | - |
Candida albicans |
| cytochrome P450 14alpha-demethylase | - |
Candida tropicalis |
| cytochrome P450 14alpha-demethylase | - |
Cryptococcus neoformans |
| cytochrome P450 14alpha-demethylase | - |
Candida parapsilosis |
| cytochrome P450 14alpha-demethylase | - |
Aspergillus fumigatus |
| cytochrome P450 14alpha-demethylase | - |
Trichophyton rubrum |
| cytochrome P450 14alpha-demethylase | - |
Nannizzia gypsea |
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Release 2023.1 (January 2023)
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