Inhibitors | Comment | Organism | Structure |
---|---|---|---|
siRNA | administrated single dose of 10 microg CYP51-siRNAs for 48 h results in significantly depletion of CYP51 mRNA in liver of mice fed on normal diet (from 40 to 60%). Exerts inhibition in a dose dependent manner (from 26% in 5 microg to 40% in 20 microg). Most inhibitive effect from day 3 to day 6 (over 50%) after treatment. Six days after administration of 30 microg CYP51-siRNAs (20 microg on day 0 and 10 microg on day 3), CYP51 mRNA and protein levels are significantly knocked down in mice liver. Low-density lipoprotein receptor expression is significantly elevated compared with controls in hepatic cells after CYP51-siRNAs. As a consequence, about 50% of sera low-density lipoprotein cholesterol are significantly reduced. Effect on low-density lipoprotein receptor increase and low-density lipoprotein cholesterol reduction lasts 8 days after a single 20 microg CYP51-siRNAs injection. CYP51-siRNAs can not cause any fatty liver compared with buffer-group and do not interfere with mice ovulation | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
CYP51 | - |
Mus musculus |
lanosterol 14-alpha demethylase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | cholesterol levels link-modulation system between cholesterol synthetic pathway through CYP51 and cholesterol transport pathway through low-density lipoprotein receptor in vivo | Mus musculus |