Application | Comment | Organism |
---|---|---|
drug development | CYP51 is a prime target of antifungal drugs | Penicillium digitatum |
Cloned (Comment) | Organism |
---|---|
gene CYP51, DNA and amino acid sequence determination and analysis, sequence comparison, expression of His-tagged enzyme in Escherichia coli strain BL21 (DE3) | Penicillium digitatum |
Protein Variants | Comment | Organism |
---|---|---|
additional information | determination of four naturally occuring polymorphisms or mutation in the CYP51 sequence, overview | Penicillium digitatum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diniconazole | homology modeling and docking model | Penicillium digitatum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Penicillium digitatum | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | a cytochrome P450 enzyme, heme iron | Penicillium digitatum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
59000 | - |
x * 59000, recombinant enzyme, SDS-PAGE | Penicillium digitatum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Penicillium digitatum | CYP51 is one of the key enzymes of sterol biosynthesis in biological kingdoms and is a prime target of antifungal drugs | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Penicillium digitatum | A1XG20 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged enzyme from Escherichia coli strain BL21 (DE3) by nickel affinity chromatography | Penicillium digitatum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | CYP51 is one of the key enzymes of sterol biosynthesis in biological kingdoms and is a prime target of antifungal drugs | Penicillium digitatum | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 59000, recombinant enzyme, SDS-PAGE | Penicillium digitatum |
More | structure homology modeling and docking model | Penicillium digitatum |
Synonyms | Comment | Organism |
---|---|---|
CYP51 | - |
Penicillium digitatum |
sterol 14alpha-demethylase | - |
Penicillium digitatum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Penicillium digitatum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Penicillium digitatum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | a cytochrome P450 enzyme | Penicillium digitatum | |
heme | - |
Penicillium digitatum |