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Literature summary for 1.14.14.154 extracted from

  • Zhao, L.; Liu, D.; Zhang, Q.; Zhang, S.; Wan, J.; Xiao, W.
    Expression and homology modeling of sterol 14alpha-demethylase from Penicillium digitatum (2007), FEMS Microbiol. Lett., 277, 37-43.
    View publication on PubMed

Application

Application Comment Organism
drug development CYP51 is a prime target of antifungal drugs Penicillium digitatum

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP51, DNA and amino acid sequence determination and analysis, sequence comparison, expression of His-tagged enzyme in Escherichia coli strain BL21 (DE3) Penicillium digitatum

Protein Variants

Protein Variants Comment Organism
additional information determination of four naturally occuring polymorphisms or mutation in the CYP51 sequence, overview Penicillium digitatum

Inhibitors

Inhibitors Comment Organism Structure
diniconazole homology modeling and docking model Penicillium digitatum

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Penicillium digitatum
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ a cytochrome P450 enzyme, heme iron Penicillium digitatum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
59000
-
x * 59000, recombinant enzyme, SDS-PAGE Penicillium digitatum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Penicillium digitatum CYP51 is one of the key enzymes of sterol biosynthesis in biological kingdoms and is a prime target of antifungal drugs ?
-
?

Organism

Organism UniProt Comment Textmining
Penicillium digitatum A1XG20
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged enzyme from Escherichia coli strain BL21 (DE3) by nickel affinity chromatography Penicillium digitatum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CYP51 is one of the key enzymes of sterol biosynthesis in biological kingdoms and is a prime target of antifungal drugs Penicillium digitatum ?
-
?

Subunits

Subunits Comment Organism
? x * 59000, recombinant enzyme, SDS-PAGE Penicillium digitatum
More structure homology modeling and docking model Penicillium digitatum

Synonyms

Synonyms Comment Organism
CYP51
-
Penicillium digitatum
sterol 14alpha-demethylase
-
Penicillium digitatum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Penicillium digitatum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Penicillium digitatum

Cofactor

Cofactor Comment Organism Structure
cytochrome P450 a cytochrome P450 enzyme Penicillium digitatum
heme
-
Penicillium digitatum