Cloned (Comment) | Organism |
---|---|
expression of N-terminally GFP-tagged enzyme in strain FYN8 under control of the GAL1 promoter | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a deletion mutant strain DELTAerg11, the defect is lethal, but mutants survive in a DELTAerg3 background, erg11/erg3 mutant lacks ergosterol but compensates the lack, sterol distrubution is altered, mutant sterol composition and phenotype, overview | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | distribution of Erg proteins between endoplasmic reticulum and liquid particles in wild-type and DELTAerg11-DELTAerg3 mutant, overview | Saccharomyces cerevisiae | 5783 | - |
membrane | - |
Saccharomyces cerevisiae | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Saccharomyces cerevisiae | deletion of the enzyme is lethal | 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Saccharomyces cerevisiae FY1679 | deletion of the enzyme is lethal | 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Saccharomyces cerevisiae FY1679 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Saccharomyces cerevisiae | 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | deletion of the enzyme is lethal | Saccharomyces cerevisiae | 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Saccharomyces cerevisiae FY1679 | 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | deletion of the enzyme is lethal | Saccharomyces cerevisiae FY1679 | 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Erg11p | - |
Saccharomyces cerevisiae |
lanosterol C-14 demethylase | - |
Saccharomyces cerevisiae |