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Literature summary for 1.14.14.154 extracted from

  • Ott, R.G.; Athenstaedt, K.; Hrastnik, C.; Leitner, E.; Bergler, H.; Daum, G.
    Flux of sterol intermediates in a yeast strain deleted of the lanosterol C-14 demethylase Erg11p (2005), Biochim. Biophys. Acta, 1735, 111-118.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of N-terminally GFP-tagged enzyme in strain FYN8 under control of the GAL1 promoter Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information construction of a deletion mutant strain DELTAerg11, the defect is lethal, but mutants survive in a DELTAerg3 background, erg11/erg3 mutant lacks ergosterol but compensates the lack, sterol distrubution is altered, mutant sterol composition and phenotype, overview Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum distribution of Erg proteins between endoplasmic reticulum and liquid particles in wild-type and DELTAerg11-DELTAerg3 mutant, overview Saccharomyces cerevisiae 5783
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membrane
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Saccharomyces cerevisiae 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 Saccharomyces cerevisiae deletion of the enzyme is lethal 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 Saccharomyces cerevisiae FY1679 deletion of the enzyme is lethal 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
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Saccharomyces cerevisiae FY1679
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
Saccharomyces cerevisiae 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 deletion of the enzyme is lethal Saccharomyces cerevisiae 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
Saccharomyces cerevisiae FY1679 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 deletion of the enzyme is lethal Saccharomyces cerevisiae FY1679 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
Erg11p
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Saccharomyces cerevisiae
lanosterol C-14 demethylase
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Saccharomyces cerevisiae