Literature summary for 1.14.14.154 extracted from

Matsuura, K.; Yoshioka, S.; Tosha, T.; Hori, H.; Ishimori, K.; Kitagawa, T.; Morishima, I.; Kagawa, N.; Waterman, M.R.
Structural diversities of active site in clinical azole-bound forms between sterol 14alpha-demethylases (CYP51s) from human and Mycobacterium tuberculosis (2005), J. Biol. Chem., 280, 9088-9096.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-phenylimidazole	Kd-value 9.1 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme	Homo sapiens
2-phenylimidazole	Kd-value 2.1 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme	Mycobacterium tuberculosis
4-phenylimidazole	Kd-value 0.19 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme	Homo sapiens
4-phenylimidazole	Kd-value 0.29 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme	Mycobacterium tuberculosis
fluconazole	Kd-value 0.12 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme	Homo sapiens
fluconazole	Kd-value 0.02 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme	Mycobacterium tuberculosis
ketoconazole	Kd-value 0.008 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme	Homo sapiens
ketoconazole	Kd-value 0.019 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mycobacterium tuberculosis	P9WPP9	-	-
Mycobacterium tuberculosis H37Rv	P9WPP9	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	analysis of active site by spectroscopic titration, resonance Raman spectroscopy and EPR	Mycobacterium tuberculosis	?	-	?
additional information	analysis of active site by stectroscopic titration, resonance Raman spectroscopy and EPR	Homo sapiens	?	-	?
additional information	analysis of active site by spectroscopic titration, resonance Raman spectroscopy and EPR	Mycobacterium tuberculosis H37Rv	?	-	?

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Release 2023.1 (January 2023)