Application | Comment | Organism |
---|---|---|
medicine | target for cholesterol-lowering drugs | Rattus norvegicus |
pharmacology | target for cholesterol-lowering drugs | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
cDNA, cloning and functional expression | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
azalanstat | specific inhibitor, IC50 less than 0.000002 mM | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55050 | - |
amino acid analysis | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | lanosta-8,24-dien-3beta-ol | 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol | 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | Rattus norvegicus | enzyme of cholesterol biosynthesis | ? | - |
? | |
additional information | Rattus norvegicus | enzyme for regulation of cholesterol biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q64654 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a 14alpha-methylsteroid + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = a DELTA14-steroid + formate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O | regulation | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | lanosta-8,24-dien-3beta-ol | Rattus norvegicus | 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol | Rattus norvegicus | 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | enzyme of cholesterol biosynthesis | Rattus norvegicus | ? | - |
? | |
additional information | enzyme for regulation of cholesterol biosynthesis | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
rLDM | rat lanosterol 14alpha-demethylase | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | - |
Rattus norvegicus | |
heme | heme-thiolate enzyme | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000002 | - |
specific inhibitor, IC50 less than 0.000002 mM | Rattus norvegicus | azalanstat |