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Literature summary for 1.14.14.146 extracted from
- Geranylgeraniol-18-hydroxylase: the last enzyme in the plaunotol biosynthetic pathway in Croton sublyratus (1998), Phytochemistry, 47, 1241-1246.
No PubMed abstract available
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2 | Croton sublyratus | this enzyme is involved in the final step of the biosynthetic pathway of plaunotol, an antipeptic ulcer constituent accumulated in this plant | 18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Croton sublyratus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Croton sublyratus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Croton sublyratus | 18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2 | this enzyme is involved in the final step of the biosynthetic pathway of plaunotol, an antipeptic ulcer constituent accumulated in this plant | Croton sublyratus | 18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2 | NADH shows about 70% of the activity with NADPH | Croton sublyratus | 18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| geranylgeraniol-18-hydroxylase | - |
Croton sublyratus |
| GGOH-18-hydroxylase | - |
Croton sublyratus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 100 | - |
activity in the heated cell-free extract increases steadily during the first 30 min of the treatment. Thereafter, the enzyme activity declines rapidly and is almost undetectable after 60 min | Croton sublyratus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
assay at | Croton sublyratus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
above and below the pH optimum (pH 5) activity declines rapidly and is undetectable after 60 min | Croton sublyratus |
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Release 2023.1 (January 2023)
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