Literature summary for 1.14.14.14 extracted from

Baravalle, R.; Valetti, F.; Catucci, G.; Gambarotta, G.; Chiesa, M.; Maurelli, S.; Giamello, E.; Barone, I.; Catalano, S.; Ando, S.; Di Nardo, G.; Gilardi, G.
Effect of sildenafil on human aromatase activity From in vitro structural analysis to catalysis and inhibition in cells (2017), J. Steroid Biochem. Mol. Biol., 165, 438-447 .

Inhibitors

Inhibitors	Comment	Organism	Structure
sildenafil	partial and mixed inhibitor with a maximal inhibition of 35%, KD value 0.58 mM. Sildenafil binds to the heme iron via its 6th axial water ligand	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	P11511	-	-

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Release 2023.1 (January 2023)