Protein Variants | Comment | Organism |
---|---|---|
D309N | mutant retains its ability to bind to androstenedione across the entire pH range studied | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
anastrozole | azole inhibitor, binding is independent of pH | Homo sapiens | |
exemestane | steroidal inhibitor, binding is dependent of pH | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
androst-4-ene-3,17-dione | the Km values increase 1.5fold from pH 6.5 to 7.4similar to the Kd values, temperature not specified in the publication | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P11511 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins | - |
Homo sapiens | estrone + formate + 4 H2O + 3 oxidized flavoproteins | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP19A1 | - |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
androstenedione binding is pH-dependent. The apparent pKa for Asp309 is 8.2, and the residue is protonated at physiological pH. A D309N mutant binds androstenedione across the entire pH range studied | Homo sapiens |