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Literature summary for 1.14.14.139 extracted from

  • Lee, Y.K.; Schmidt, D.R.; Cummins, C.L.; Choi, M.; Peng, L.; Zhang, Y.; Goodwin, B.; Hammer, R.E.; Mangelsdorf, D.J.; Kliewer, S.A.
    Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis (2008), Mol. Endocrinol., 22, 1345-1356.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme expression is repressed by the nuclear bile acid receptor FXR Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus a key step in bile acid synthesis 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
additional information Mus musculus while Cyp8b1 repression by the nuclear bile acid receptor FXR is also intact in mice deficient for liver receptor homolog 1, LRH-1, in hepatocytes, basal CYP8B1 mRNA levels are significantly decreased and there are corresponding changes in the composition of the bile acid pool. Liver receptor homolog 1, LRH-1, is either not involved in the feedback regulation of bile acid synthesis or is compensated for by other factors ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
Mus musculus 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 a key step in bile acid synthesis Mus musculus 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
additional information while Cyp8b1 repression by the nuclear bile acid receptor FXR is also intact in mice deficient for liver receptor homolog 1, LRH-1, in hepatocytes, basal CYP8B1 mRNA levels are significantly decreased and there are corresponding changes in the composition of the bile acid pool. Liver receptor homolog 1, LRH-1, is either not involved in the feedback regulation of bile acid synthesis or is compensated for by other factors Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
CYP8B1
-
Mus musculus
sterol 12alpha-hydroxylase
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Mus musculus

Expression

Organism Comment Expression
Mus musculus in mice deficient for liver receptor homolog LRH-1, basal CYP8B1 mRNA levels are significantly decreased. CYP8B1 repression by farnesoid X receptor FXR is intact in mice deficient for LRH-1 in hepatocytes down