Cloned (Comment) | Organism |
---|---|
genetic structure and phylogenetic analysis | Mus musculus |
genetic structure and phylogenetic analysis | Homo sapiens |
genetic structure and phylogenetic analysis | Rattus norvegicus |
genetic structure and phylogenetic analysis | Sus scrofa |
genetic structure and phylogenetic analysis | Oryctolagus cuniculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | a cytochrome P450 enzyme | Mus musculus | |
Fe2+ | a cytochrome P450 enzyme | Homo sapiens | |
Fe2+ | a cytochrome P450 enzyme | Rattus norvegicus | |
Fe2+ | a cytochrome P450 enzyme | Sus scrofa | |
Fe2+ | a cytochrome P450 enzyme | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | Mus musculus | - |
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | - |
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | Sus scrofa | - |
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | Oryctolagus cuniculus | - |
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | Mus musculus | the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview | ? | - |
? | |
additional information | Homo sapiens | the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview | ? | - |
? | |
additional information | Rattus norvegicus | the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview | ? | - |
? | |
additional information | Sus scrofa | the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview | ? | - |
? | |
additional information | Oryctolagus cuniculus | the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Sus scrofa | 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Oryctolagus cuniculus | 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview | Mus musculus | ? | - |
? | |
additional information | the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview | Rattus norvegicus | ? | - |
? | |
additional information | the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview | Sus scrofa | ? | - |
? | |
additional information | the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview | Oryctolagus cuniculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP8B1 | - |
Mus musculus |
CYP8B1 | - |
Homo sapiens |
CYP8B1 | - |
Rattus norvegicus |
CYP8B1 | - |
Sus scrofa |
CYP8B1 | - |
Oryctolagus cuniculus |
More | the enzyme belongs to the CYP8B subfamily | Mus musculus |
More | the enzyme belongs to the CYP8B subfamily | Homo sapiens |
More | the enzyme belongs to the CYP8B subfamily | Rattus norvegicus |
More | the enzyme belongs to the CYP8B subfamily | Sus scrofa |
More | the enzyme belongs to the CYP8B subfamily | Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome | a cytochrome P450 enzyme | Rattus norvegicus | |
cytochrome | a cytochrome P450 enzyme | Oryctolagus cuniculus | |
cytochrome P450 | a cytochrome P450 enzyme | Mus musculus | |
cytochrome P450 | a cytochrome P450 enzyme | Homo sapiens | |
cytochrome P450 | a cytochrome P450 enzyme | Sus scrofa |