Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | feeding of cholic acid, taurine, or cholesterol does not affect expression of CYP8B1 | Rattus norvegicus | |
additional information | feeding of taurine alone has no effect on enzyme expression | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | feeding of cholic acid suppresses expression of CYP8B1, the effect is partly reversed by taurine, feeding of taurine alone has no effect on enzyme expression | Mus musculus | |
additional information | feeding of cholic acid, taurine, or cholesterol does not affect expression of CYP8B1 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | Mus musculus | - |
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | - |
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
10-weeks-old male C75BL/6 mice | - |
Rattus norvegicus | - |
5-weeks-old male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP8B1 | - |
Mus musculus |
CYP8B1 | - |
Rattus norvegicus |
sterol 12alpha-hydroxylase | - |
Mus musculus |
sterol 12alpha-hydroxylase | - |
Rattus norvegicus |