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Literature summary for 1.14.14.138 extracted from

  • Subramanian, A.; Wang, J.; Gil, G.
    STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase (1998), Nucleic Acids Res., 26, 2173-2178.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lithocholate + [reduced NADPH-hemoprotein reductase] + O2 Mesocricetus auratus the male-specific P450 catalyzes the reaction. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene. STAT 5a and STAT 5b mediates GH-dependent regulation of CYP3A10/6beta-hydroxylase promoter activity 6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
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Source Tissue

Source Tissue Comment Organism Textmining
liver male-specific enzyme. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene Mesocricetus auratus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
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Mesocricetus auratus 6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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?
lithocholate + [reduced NADPH-hemoprotein reductase] + O2 the male-specific P450 catalyzes the reaction. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene. STAT 5a and STAT 5b mediates GH-dependent regulation of CYP3A10/6beta-hydroxylase promoter activity Mesocricetus auratus 6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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?

Synonyms

Synonyms Comment Organism
3A10/lithocholic acid 6beta-hydroxylase
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Mesocricetus auratus

Cofactor

Cofactor Comment Organism Structure
cytochrome P-450
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Mesocricetus auratus