Literature summary for 1.14.14.137 extracted from

Shimomura, H.; Etoh, H.; Mizutani, M.; Hirai, N.; Todoroki, Y.
Effect of the minor ABA metabolite 7-hydroxy-ABA on Arabidopsis ABA 8-hydroxylase CYP707A3 (2007), Bioorg. Med. Chem. Lett., 17, 4977-4981.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1'-deoxy-7'-hydroxy abscisic acid	63% inhibition of the enzyme at 0.05 mM	Arabidopsis thaliana
7'-oxo abscisic acid	24% inhibition of the enzyme at 0.05 mM	Arabidopsis thaliana
additional information	pH-dependent partition coefficient of the inhibitors at different pH values, overview, no inhibition by 7'-hydroxy abscisic acid, four-step synthesis of 7'-hydroxy-abscisic acid from alpha-ionone, overview	Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(+)-abscisic acid + [reduced NADPH-hemoprotein reductase] + O2	Arabidopsis thaliana	-	8'-hydroxyabscisate + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(+)-abscisic acid + [reduced NADPH-hemoprotein reductase] + O2	-	Arabidopsis thaliana	8'-hydroxyabscisate + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
ABA 8-hydroxylase	-	Arabidopsis thaliana
CYP707A3	-	Arabidopsis thaliana

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Release 2023.1 (January 2023)