Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.136 extracted from

  • Yu, B.; Ruppert, M.; Stockigt, J.
    Deoxysarpagine hydroxylase--a novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia (2002), Bioorg. Med. Chem., 10, 2479-2483.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Ancymidole 1.0 mM, 49% inhibition Rauvolfia serpentina
BAS 110 W 1 mM, complete inhibition Rauvolfia serpentina
BAS 111 W 1 mM, 84% inhibition Rauvolfia serpentina
CO ratio CO:O2 of 9:1, 70% inhibition in the light, 80% inhibition under red light, 77% inhibition under blue light Rauvolfia serpentina
cytochrome c 0.01 mM, 46% inhibition Rauvolfia serpentina
ketoconazole 1 mM, 69% inhibition Rauvolfia serpentina
LAB 1500978 1 mM, 74% inhibition Rauvolfia serpentina
Metyrapone 1 mM, 83% inhibition Rauvolfia serpentina
NADP+ competitive inhibition Rauvolfia serpentina
Tetcyclacis 1 mM, 45% inhibition Rauvolfia serpentina

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0074
-
10-deoxysarpagine 35°C, pH 8.0 Rauvolfia serpentina

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane associated Rauvolfia serpentina 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-deoxysarpagine + [reduced NADPH-hemoprotein reductase] + O2 Rauvolfia serpentina most probably the natural substrate sarpagine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Rauvolfia serpentina
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rauvolfia serpentina

Storage Stability

Storage Stability Organism
-25°C, 20% sucrose, more than 3 months, no loss of activity Rauvolfia serpentina

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-deoxysarpagine + [reduced NADPH-hemoprotein reductase] + O2
-
Rauvolfia serpentina sarpagine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
10-deoxysarpagine + [reduced NADPH-hemoprotein reductase] + O2 most probably the natural substrate Rauvolfia serpentina sarpagine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
-
Rauvolfia serpentina

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Rauvolfia serpentina