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Literature summary for 1.14.14.118 extracted from

  • Kato, N.; Suzuki, H.; Takagi, H.; Asami, Y.; Kakeya, H.; Uramoto, M.; Usui, T.; Takahashi, S.; Sugimoto, Y.; Osada, H.
    Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus (2009), ChemBioChem, 10, 920-928.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae strain YPH500 Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus fumigatus
-
6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus fumigatus BM939
-
6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus B9WZX1
-
-
Aspergillus fumigatus BM939 B9WZX1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
-
Aspergillus fumigatus 6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
-
Aspergillus fumigatus BM939 6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
ftmC
-
Aspergillus fumigatus
FtmC protein
-
Aspergillus fumigatus

General Information

General Information Comment Organism
malfunction disruption of the ftmC gene leads to substantial accumulation of tryprostatin B and its cyclization product demethoxyfumitremorgin C Aspergillus fumigatus