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Literature summary for 1.14.14.116 extracted from

  • Yabe, K.; Matsuyama, Y.; Ando, Y.; Nakajima, H.; Hamasaki, T.
    Stereochemistry during aflatoxin biosynthesis: Conversion of norsolorinic acid to averufin (1993), Appl. Environ. Microbiol., 59, 2486-2492.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Aspergillus parasiticus 5829
-
microsome
-
Aspergillus parasiticus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(1'S)-averantin + NADPH + H+ + O2 Aspergillus parasiticus
-
(1'S,5'R)-5'-hydroxyaverantin + NADP+ + H2O
-
?
(1'S)-averantin + NADPH + H+ + O2 Aspergillus parasiticus NIAH-26
-
(1'S,5'R)-5'-hydroxyaverantin + NADP+ + H2O
-
?
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus parasiticus the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. No activity with (1'R)-averantin. The enzyme specifically hydroxylates (1'S)-averantin to both diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus parasiticus
-
(1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus parasiticus the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. No activity with (1'R)-averantin. The enzyme specifically hydroxylates (1'S)-averantin to both diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus parasiticus
-
-
-
Aspergillus parasiticus NIAH-26
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(1'S)-averantin + NADPH + H+ + O2
-
Aspergillus parasiticus (1'S,5'R)-5'-hydroxyaverantin + NADP+ + H2O
-
?
(1'S)-averantin + NADPH + H+ + O2
-
Aspergillus parasiticus NIAH-26 (1'S,5'R)-5'-hydroxyaverantin + NADP+ + H2O
-
?
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. No activity with (1'R)-averantin. The enzyme specifically hydroxylates (1'S)-averantin to both diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin Aspergillus parasiticus (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 no activity with (1'R)-averantin. The enzyme specifically hydroxylates (1'S)-averantin to both diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin Aspergillus parasiticus (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2
-
Aspergillus parasiticus (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. No activity with (1'R)-averantin. The enzyme specifically hydroxylates (1'S)-averantin to both diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin Aspergillus parasiticus (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 no activity with (1'R)-averantin. The enzyme specifically hydroxylates (1'S)-averantin to both diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin Aspergillus parasiticus (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
additional information the enzyme does not act on (1'R)-averantin Aspergillus parasiticus ?
-
?
additional information the enzyme does not act on (1'R)-averantin Aspergillus parasiticus NIAH-26 ?
-
?

Synonyms

Synonyms Comment Organism
AVN monooxygenase
-
Aspergillus parasiticus