Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | Artemisia annua | overall reaction via artemsinic alcohol and artemsinic aldehyde, multistep process | artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Artemisia annua | Q1PS23 | cv. CQF39 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | callus cannot produce artemisinin | Artemisia annua | - |
seedling | regenerated plantlets | Artemisia annua | - |
trichome | artemisinin production in Artemisia annua is localized in glandular trichomes on the surface of leaves, shoots and flowers | Artemisia annua | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | overall reaction via artemsinic alcohol and artemsinic aldehyde, multistep process | Artemisia annua | artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
amorpha-4,11-diene monooxygenase | - |
Artemisia annua |
CYP71AV1 | - |
Artemisia annua |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Artemisia annua |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH-hemoprotein reductase | A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ | Artemisia annua |
Organism | Comment | Expression |
---|---|---|
Artemisia annua | endophyte Penicillium oxalicum strain B4 induces the enzyme and leads to enhanced growth and artemisinin content of host plant in an in vitro dual culture of endophyte with regenerated plantlets via generation of reactive oxygen species (ROS) including superoxide ions and H2O2 | up |