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Literature summary for 1.14.14.114 extracted from

  • Zheng, L.; Tian, H.; Yuan, Y.; Wang, J.
    The influence of endophytic Penicillium oxalicum B4 on growth and artemisinin biosynthesis of in vitro propagated plantlets of Artemisia annua L. (2016), Plant Growth Regul., 80, 93-102 .
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] Artemisia annua overall reaction via artemsinic alcohol and artemsinic aldehyde, multistep process artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
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Organism

Organism UniProt Comment Textmining
Artemisia annua Q1PS23 cv. CQF39
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Source Tissue

Source Tissue Comment Organism Textmining
additional information callus cannot produce artemisinin Artemisia annua
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seedling regenerated plantlets Artemisia annua
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trichome artemisinin production in Artemisia annua is localized in glandular trichomes on the surface of leaves, shoots and flowers Artemisia annua
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] overall reaction via artemsinic alcohol and artemsinic aldehyde, multistep process Artemisia annua artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
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?

Synonyms

Synonyms Comment Organism
amorpha-4,11-diene monooxygenase
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Artemisia annua
CYP71AV1
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Artemisia annua

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
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assay at Artemisia annua

Cofactor

Cofactor Comment Organism Structure
NADPH-hemoprotein reductase A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ Artemisia annua

Expression

Organism Comment Expression
Artemisia annua endophyte Penicillium oxalicum strain B4 induces the enzyme and leads to enhanced growth and artemisinin content of host plant in an in vitro dual culture of endophyte with regenerated plantlets via generation of reactive oxygen species (ROS) including superoxide ions and H2O2 up