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Literature summary for 1.14.14.114 extracted from
- Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua (2009), Botany, 87, 635-642.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Artemisia annua |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0026 | - |
artemisinic aldehyde | pH 8.5, 30°C | Artemisia annua |  |
| 0.0088 | - |
dihydroartemisinic aldehyde | pH 8.5, 30°C | Artemisia annua | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 53800 | - |
x * 53800, calculated | Artemisia annua |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Artemisia annua | - |
- |
- |
| Artemisia annua | C5I9X1 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| trichome | glandular secretory trichome | Artemisia annua | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-nonenal + [reduced NADPH-hemoprotein reductase] + O2 | - |
Artemisia annua | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| amorpha-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2 | - |
Artemisia annua | artemisinic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| artemisinic alcohol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Artemisia annua | artemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| artemisinic aldehyde + [reduced NADPH-hemoprotein reductase] + O2 | - |
Artemisia annua | artemisinate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| dihydroartemisinic alcohol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Artemisia annua | dihydroartemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| dihydroartemisinic alcohol + [reduced NADPH-hemoprotein reductase] + O2 | about 50% of the rate with artemisinic alcohol | Artemisia annua | dihydroartemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| dihydroartemisinic aldehyde + [reduced NADPH-hemoprotein reductase] + O2 | - |
Artemisia annua | dihydroartemisinate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| additional information | no substrate: dihydroartemisinic aldehyde | Artemisia annua | ? | - |
? | |
| additional information | no substrates: Sinapaldehyde, 2-phenylpropanal | Artemisia annua | ? | - |
? | |
| octanal + [reduced NADPH-hemoprotein reductase] + O2 | - |
Artemisia annua | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 53800, calculated | Artemisia annua |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ALDH1 | - |
Artemisia annua |
| CYP71AV1 | - |
Artemisia annua |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.53 | - |
artemisinic aldehyde | pH 8.5, 30°C | Artemisia annua | |
| 7.74 | - |
dihydroartemisinic aldehyde | pH 8.5, 30°C | Artemisia annua | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
substrate dihydroartemisinic aldehyde | Artemisia annua |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 593 | - |
artemisinic aldehyde | pH 8.5, 30°C | Artemisia annua | |
| 881 | - |
dihydroartemisinic aldehyde | pH 8.5, 30°C | Artemisia annua | |
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Release 2023.1 (January 2023)
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