Literature summary for 1.14.14.113 extracted from

Harada, H.; Shindo, K.; Iki, K.; Teraoka, A.; Okamoto, S.; Yu, F.; Hattan, J.; Utsumi, R.; Misawa, N.
Efficient functional analysis system for cyanobacterial or plant cytochromes P450 involved in sesquiterpene biosynthesis (2011), Appl. Microbiol. Biotechnol., 90, 467-476.

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Cloned(Commentary)

Cloned (Comment)	Organism
CYP71BA1 expression in Escherichia coli. Co-expression with germacrene A hydroxylase P450NSor CYP110C1 from Nostoc sp. PCC 7120 and the Arabidopsis thaliana ATR2 as well as two corresponding enzymes derived from Zingiber officinale, named ZoRED1 and ZoRED2 from one singel expression plasmid, construction, overview. The co-expression enhances CYP71BA1 expression levels by 1.5-2fold comapred to single heterologous expression	Zingiber zerumbet

Cloned (Comment)

Organism

CYP71BA1 expression in Escherichia coli. Co-expression with germacrene A hydroxylase P450NSor CYP110C1 from Nostoc sp. PCC 7120 and the Arabidopsis thaliana ATR2 as well as two corresponding enzymes derived from Zingiber officinale, named ZoRED1 and ZoRED2 from one singel expression plasmid, construction, overview. The co-expression enhances CYP71BA1 expression levels by 1.5-2fold comapred to single heterologous expression

Zingiber zerumbet

Protein Variants

Protein Variants	Comment	Organism
additional information	reconstruction of the isoprenoid biosynthetic pathway in Escherichia coli, overview	Zingiber zerumbet

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	cytochrome P450 enzyme	Zingiber zerumbet

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
alpha-humulene + O2 + [reduced NADPH-hemoprotein reductase]	Zingiber zerumbet	-	10-hydroxy-alpha-humulene + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Zingiber zerumbet	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
alpha-humulene + O2 + [reduced NADPH-hemoprotein reductase]	-	Zingiber zerumbet	10-hydroxy-alpha-humulene + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
alpha-humulene-8-hydroxylase	-	Zingiber zerumbet
CYP71BA1	-	Zingiber zerumbet

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome P450	-	Zingiber zerumbet

General Information

General Information	Comment	Organism
evolution	the enzyme belongs to the cytochrome P450 monooxygenases	Zingiber zerumbet