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Literature summary for 1.14.14.105 extracted from

  • Schoendorf, A.; Rithner, C.D.; Williams, R.M.; Croteau, R.B.
    Molecular cloning of a cytochrome P450 taxane 10beta-hydroxylase cDNA from Taxus and functional expression in yeast (2001), Proc. Natl. Acad. Sci. USA, 98, 1501-1506.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Taxus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information in vivo and in vitro assay in yeast for recombinant enzyme Taxus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Taxus sp. catalyzes early step in taxol biosynthesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Taxus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Taxus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information catalyzes early step in taxol biosynthesis Taxus sp. ?
-
 ?
taxa-4(20),11-dien-5alpha-yl acetate + [reduced NADPH-hemoprotein reductase] + O2
-
 Taxus sp. 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
 Taxus sp.