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Literature summary for 1.14.14.102 extracted from

  • Samanani, N.; Alcantara, J.; Bourgault, R.; Zulak, K.G.; Facchini, P.J.
    The role of phloem sieve elements and laticifers in the biosynthesis and accumulation of alkaloids in opium poppy (2006), Plant J., 47, 547-563.
    View publication on PubMed
Search for more literature for 1.14.14.102

Cloned(Commentary)

Cloned (Comment) Organism
heterologous expression Papaver somniferum

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane membrane-bound, in sieve element ER Papaver somniferum 5789
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additional information subcellular localization study Papaver somniferum
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-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ P450-dependent hydroxylase Papaver somniferum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 Papaver somniferum the catalyzes step 5 in the unique, cell type-specific biosynthesis of benzylisoquinoline alkaloids in the opium poppy, biosynthetic pathway leading from L-DOPA to morphine, overview (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Papaver somniferum
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 cv. Louisiana
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Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Papaver somniferum

Source Tissue

Source Tissue Comment Organism Textmining
phloem localization in the sieve elements adjacent or proximal to laticifers in the root and hypocotyl of opium poppy seedlings Papaver somniferum
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root phloem Papaver somniferum
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seedling root phloem, the abundance of the enzyme increases rapidly between 1 and 3 days after seed germination Papaver somniferum
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2
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 Papaver somniferum (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 the catalyzes step 5 in the unique, cell type-specific biosynthesis of benzylisoquinoline alkaloids in the opium poppy, biosynthetic pathway leading from L-DOPA to morphine, overview Papaver somniferum (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
(S)-N-methylcoclaurine 3'-hydroxylase
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 Papaver somniferum
CYP80B1
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 Papaver somniferum

Cofactor

Cofactor Comment Organism Structure
cytochrome P450 P450-dependent hydroxylase Papaver somniferum