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Literature summary for 1.14.14.1 extracted from

  • Lavado, R.; Li, J.; Rimoldi, J.; Schlenk, D.
    Evaluation of the stereoselective biotransformation of permethrin in human liver microsomes Contributions of cytochrome P450 monooxygenases to the formation of estrogenic metabolites (2014), Toxicol. Lett., 226, 192-197 .
    View publication on PubMed
Search for more literature for 1.14.14.1

Application

Application Comment Organism
medicine during degradation of permethrins, potential dispositional differences may occur with permethrin enantiomers. Cleavage of pyrethroid esters leads to detoxification of the acute neurological effects, but formation of the benzyl alcohol and hydroxylated metabolite may lead to estrogenic responses Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ketoconazole
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.055
-
 (1R)-cis-permethrin product 3-(4'-hydroxyphenoxy)-benzyl alcohol, pH 7.4,37°C Homo sapiens
0.057
-
 (1S)-cis-permethrin product 3-(4'-hydroxyphenoxy)-benzyl alcohol, pH 7.4,37°C Homo sapiens
0.061
-
 (1R)-cis-permethrin product 3-phenoxybenzyl alcohol, pH 7.4,37°C Homo sapiens
0.063
-
 (1S)-cis-permethrin product 3-phenoxybenzyl alcohol, pH 7.4,37°C Homo sapiens
0.101
-
 (1S)-trans-permethrin product 3-phenoxybenzyl alcohol, pH 7.4,37°C Homo sapiens
0.106
-
 (1S)-trans-permethrin product 3-(4'-hydroxyphenoxy)-benzyl alcohol, pH 7.4,37°C Homo sapiens
0.115
-
 (1R)-trans-permethrin product 3-(4'-hydroxyphenoxy)-benzyl alcohol, pH 7.4,37°C Homo sapiens
0.131
-
 (1R)-trans-permethrin product 3-phenoxybenzyl alcohol, pH 7.4,37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(1R)-cis-permethrin + O2 + [reduced NADPH-hemoprotein reductase]
-
 Homo sapiens 3-phenoxybenzyl alcohol + 3-(4'-hydroxyphenoxy)-benzyl alcohol + [oxidized NADPH-hemoprotein reductase]
-
 ?
(1R)-trans-permethrin + O2 + [reduced NADPH-hemoprotein reductase]
-
 Homo sapiens 3-phenoxybenzyl alcohol + 3-(4'-hydroxyphenoxy)-benzyl alcohol + [oxidized NADPH-hemoprotein reductase]
-
 ?
(1S)-cis-permethrin + O2 + [reduced NADPH-hemoprotein reductase]
-
 Homo sapiens 3-phenoxybenzyl alcohol + 3-(4'-hydroxyphenoxy)-benzyl alcohol + [oxidized NADPH-hemoprotein reductase]
-
 ?
(1S)-trans-permethrin + O2 + [reduced NADPH-hemoprotein reductase]
-
 Homo sapiens 3-phenoxybenzyl alcohol + 3-(4'-hydroxyphenoxy)-benzyl alcohol + [oxidized NADPH-hemoprotein reductase]
-
 ?
additional information (1R)-trans-permethrin is the best substrate among the permethrin enantiomers Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CYP3A4
-
 Homo sapiens