Cloned (Comment) | Organism |
---|---|
expression in V79 Chinese hamster fibroblasts and Hep-G2 cells, coexpression with N(O)-acetyltransferase or sulfotransferase 1A1-1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | only sour cherry, blueberry, and black currant juices suppress the first step of xenobiotic enzymatic activation by CYP1A2, whereas most plant-derived beverages, from diverse plants, inhibit the second step catalyzed by other enzymes, relative inhibition rates, detailed overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine + [reduced NADPH-hemoprotein reductase] + O2 | CYP1A2 catalyzes the first step of activation of the xenobiotic compound and its genotoxic effect, the second step is catalyzed by the sulfotransferase 1A1-1 | Homo sapiens | ? | - |
? | |
2-amino-3-methylimidazo[4,5-f]quinoline + [reduced NADPH-hemoprotein reductase] + O2 | CYP1A2 catalyzes the first step of activation of the xenobiotic compound and its genotoxic effect, the second step is catalyzed by the N(O)-acetyltransferase. | Homo sapiens | ? | - |
? | |
additional information | CYP1A2 catalyzes the O-demethylation of 7-methoxyresorufin | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP1A2 | - |
Homo sapiens |
cytochrome P450-dependent monooxygenase 1A2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens |