Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | ? | - |
? | |
additional information | Homo sapiens | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | ? | - |
? | |
additional information | Rattus norvegicus | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
CYP4A11 | - |
Mus musculus | - |
isozyme Cyp4a12 | - |
Rattus norvegicus | - |
isozyme CYP4A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adrenic acid + [reduced NADPH-hemoprotein reductase] + O2 | i.e. all-cis-7,10,13,16-docosatetraenoic acid | Mus musculus | ? | - |
? | |
adrenic acid + [reduced NADPH-hemoprotein reductase] + O2 | i.e. all-cis-7,10,13,16-docosatetraenoic acid | Homo sapiens | ? | - |
? | |
adrenic acid + [reduced NADPH-hemoprotein reductase] + O2 | i.e. all-cis-7,10,13,16-docosatetraenoic acid | Rattus norvegicus | ? | - |
? | |
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | ? | - |
? | |
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 20-hydroxyeicosatetraenoic acid + 19-hydroxyeicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | ratio 12:1 | ? | |
docosahexaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | 22-hydroxydocosahexaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
docosahexaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 22-hydroxydocosahexaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
docosahexaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 22-hydroxydocosahexaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
eicosapentaenoic acid + NADPH + H+ + O2 | - |
Homo sapiens | 20-hydroxyeicosapentaenoic acid + NADP+ + H2O | - |
? | |
eicosapentaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 20-hydroxyeicosapentaenoic acid + 19-hydroxyeicosapentaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | ratio 4:3 | ? | |
eicosapentaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | 20-hydroxyeicosapentaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
linoleic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | (9Z,12Z)-18-hydroxyoctadeca-9,12-dienoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
linoleic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | (9Z,12Z)-18-hydroxyoctadeca-9,12-dienoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
linoleic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | (9Z,12Z)-18-hydroxyoctadeca-9,12-dienoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | Mus musculus | ? | - |
? | |
additional information | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | Homo sapiens | ? | - |
? | |
additional information | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | Rattus norvegicus | ? | - |
? | |
additional information | the enzyme shows (omega-1)-hydroxylase activity against arachidonic acid, linoleic acid, and especially against eicosapentaenoic acid and docosahexaenoic acid, substrate specificities of isozymes, overview | Mus musculus | ? | - |
? | |
additional information | the enzyme shows (omega-1)-hydroxylase activity against arachidonic acid, linoleic acid, and especially against eicosapentaenoic acid and docosahexaenoic acid, substrate specificities of isozymes, overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme shows (omega-1)-hydroxylase activity against arachidonic acid, linoleic acid, and especially against eicosapentaenoic acid and docosahexaenoic acid, substrate specificities of isozymes, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AA omega-hydroxylase | - |
Mus musculus |
AA omega-hydroxylase | - |
Homo sapiens |
AA omega-hydroxylase | - |
Rattus norvegicus |
CYP4F2 | - |
Mus musculus |
CYP4F3A | - |
Mus musculus |
CYP4F3B | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | cytochrome P450-dependent metabolism of omega-6 polyunsaturated fatty acids, overview | Mus musculus |
metabolism | cytochrome P450-dependent metabolism of omega-6 polyunsaturated fatty acids, overview | Homo sapiens |
metabolism | cytochrome P450-dependent metabolism of omega-6 polyunsaturated fatty acids, overview | Rattus norvegicus |