Application | Comment | Organism |
---|---|---|
pharmacology | kynurenine represents a branch point of the kynurenine pathway, being converted into the neurotoxin 3-hydroxykynurenine via kynurenine monooxygenase, neuroprotectant kynurenic acid, and anthranilic acid. As a result of this branch point, kynurenine monooxygenase is an attractive drug target for several neurodegenerative and/or neuroinflammatory diseases, especially Huntington's, Alzheimer's, and Parkinson's diseases | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ro 61-8048 | - |
Pseudomonas fluorescens | |
Ro 61-8048 | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial membrane | the C terminus of the enzyme contains a putative outer mitochondrial membrane-targeting sequence and this portion of the molecule is required enzyme function | Sus scrofa | 31966 | - |
mitochondrial membrane | the C terminus of the enzyme contains a putative outer mitochondrial membrane-targeting sequence and this portion of the molecule is required enzyme function | Homo sapiens | 31966 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15229 | - |
- |
Pseudomonas fluorescens | Q84HF5 | - |
- |
Rattus norvegicus | O88867 | - |
- |
Sus scrofa | Q9MZS9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
CHO cell | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | flavoenzyme | Sus scrofa | |
FAD | flavoenzyme | Pseudomonas fluorescens | |
FAD | flavoenzyme | Homo sapiens | |
FAD | flavoenzyme | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
drug target | kynurenine represents a branch point of the kynurenine pathway, being converted into the neurotoxin 3-hydroxykynurenine via kynurenine monooxygenase, neuroprotectant kynurenic acid, and anthranilic acid. As a result of this branch point, kynurenine monooxygenase is an attractive drug target for several neurodegenerative and/or neuroinflammatory diseases, especially Huntington's, Alzheimer's, and Parkinson's diseases | Homo sapiens |
malfunction | human polymorphism in the C-terminal region of the enzyme results in an Arg452Cys mutation, statistically linked to bipolar disorder and schizophrenia | Homo sapiens |
metabolism | enzyme of the kynurenine pathway, which is the major catabolic route of tryptophan | Homo sapiens |