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Literature summary for 1.14.13.9 extracted from

  • Smith, J.R.; Jamie, J.F.; Guillemin, G.J.
    Kynurenine-3-monooxygenase a review of structure, mechanism, and inhibitors (2016), Drug Discov. Today, 21, 315-324 .
    View publication on PubMed

Application

Application Comment Organism
pharmacology kynurenine represents a branch point of the kynurenine pathway, being converted into the neurotoxin 3-hydroxykynurenine via kynurenine monooxygenase, neuroprotectant kynurenic acid, and anthranilic acid. As a result of this branch point, kynurenine monooxygenase is an attractive drug target for several neurodegenerative and/or neuroinflammatory diseases, especially Huntington's, Alzheimer's, and Parkinson's diseases Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ro 61-8048
-
Pseudomonas fluorescens
Ro 61-8048
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane the C terminus of the enzyme contains a putative outer mitochondrial membrane-targeting sequence and this portion of the molecule is required enzyme function Sus scrofa 31966
-
mitochondrial membrane the C terminus of the enzyme contains a putative outer mitochondrial membrane-targeting sequence and this portion of the molecule is required enzyme function Homo sapiens 31966
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O15229
-
-
Pseudomonas fluorescens Q84HF5
-
-
Rattus norvegicus O88867
-
-
Sus scrofa Q9MZS9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
CHO cell
-
Homo sapiens
-
kidney
-
Rattus norvegicus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Cofactor

Cofactor Comment Organism Structure
FAD flavoenzyme Sus scrofa
FAD flavoenzyme Pseudomonas fluorescens
FAD flavoenzyme Homo sapiens
FAD flavoenzyme Rattus norvegicus

General Information

General Information Comment Organism
drug target kynurenine represents a branch point of the kynurenine pathway, being converted into the neurotoxin 3-hydroxykynurenine via kynurenine monooxygenase, neuroprotectant kynurenic acid, and anthranilic acid. As a result of this branch point, kynurenine monooxygenase is an attractive drug target for several neurodegenerative and/or neuroinflammatory diseases, especially Huntington's, Alzheimer's, and Parkinson's diseases Homo sapiens
malfunction human polymorphism in the C-terminal region of the enzyme results in an Arg452Cys mutation, statistically linked to bipolar disorder and schizophrenia Homo sapiens
metabolism enzyme of the kynurenine pathway, which is the major catabolic route of tryptophan Homo sapiens