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Literature summary for 1.14.13.8 extracted from

  • Saraav, I.; Pandey, K.; Misra, R.; Singh, S.; Sharma, M.; Sharma, S.
    Characterization of MymA protein as a flavin-containing monooxygenase and as a target of isoniazid (2017), Chem. Biol. Drug Des., 89, 152-160 .
    View publication on PubMed
Search for more literature for 1.14.13.8

Inhibitors

Inhibitors Comment Organism Structure
isoniazid
-
 Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0202
-
 trimethylamine at pH 8.0 and 30°C Mycobacterium tuberculosis
0.0385
-
 Thiourea at pH 8.0 and 30°C Mycobacterium tuberculosis

Localization

Localization Comment Organism GeneOntology No. Textmining
cell wall
-
 Mycobacterium tuberculosis 5618
-

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with glutathione Mycobacterium tuberculosis ?
-
 ?
thiourea + NADPH + H+ + O2
-
 Mycobacterium tuberculosis ?
-
 ?
trimethylamine + NADPH + H+ + O2
-
 Mycobacterium tuberculosis ?
-
 ?

Subunits

Subunits Comment Organism
? x * 55500, SDS-PAGE Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
FMO
-
 Mycobacterium tuberculosis
MymA
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Mycobacterium tuberculosis
NADPH
-
 Mycobacterium tuberculosis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0049
-
 at pH 8.0 and 30°C Mycobacterium tuberculosis isoniazid