Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.13.8 extracted from

  • Siddens, L.K.; Krueger, S.K.; Henderson, M.C.; Williams, D.E.
    Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide (2014), Biochem. Pharmacol., 89, 141-147 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.13.8

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cell microsomes Homo sapiens

Protein Variants

Protein Variants Comment Organism
N413K the mutant of isoform FMO2 exhibits higher catalytic activity toward methyl-4-tolyl sulfide compared to the wild type enzyme Homo sapiens
S195L the mutant of isoform FMO2 exhibits lower catalytic activity toward methyl-4-tolyl sulfide and ethylene thiourea compared to the wild type enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ethylene thiourea + NADPH + H+ + O2
-
 Homo sapiens ?
-
 ?
methyl-4-tolyl sulfide + NADPH + H+ + O2
-
 Homo sapiens ?
-
 ?
trimethylamine + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens trimethylamine N-oxide + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
FMO1 isoform Homo sapiens
FMO2 isoform Homo sapiens
FMO3 isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
NADPH
-
 Homo sapiens