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Literature summary for 1.14.13.8 extracted from

  • Celius, T.; Pansoy, A.; Matthews, J.; Okey, A.B.; Henderson, M.C.; Krueger, S.K.; Williams, D.E.
    Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver (2010), Toxicol. Appl. Pharmacol., 247, 60-69.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.13.8

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus P97501 gene Fmo3; gene FMO3
-

Source Tissue

Source Tissue Comment Organism Textmining
Hepa-1 cell
-
 Mus musculus
-
Hepa-1c1c7 cell
-
 Mus musculus
-
hepatocyte
-
 Mus musculus
-
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ethionamide + NADPH + H+ + O2
-
 Mus musculus ethionamide N-oxide + NADP+ + H2O
-
 ?
sulindac sulfide + NADPH + H+ + O2
-
 Mus musculus sulindac + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
flavin-containing monooxygenase-3
-
 Mus musculus
FMO3
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
flavin
-
 Mus musculus
NADPH
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus no induction of FMO3 in Hepa-1 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin, DMSO, beta-naphthoflavon, 3,3',4,4',5-pentachlorobiphenyl, butylated hydroxyanisole, menadione, sulphoraphane, and tert-butylhydroquinone additional information
Mus musculus 8fold induction of FMO3 in liver by 3-methylcholanthrene. In Hepa-1 cells, 3-methylcholanthrene and benzo[a]pyrene induce FMO3 mRNA by about 30fold in an aryl hydrocarbon receptor-dependent manner. Aryl hydrocarbon receptor, AHR, dependent induction of FMO mRNAs in liver by 2,3,7,8-tetrachlorodibenzo-p-dioxin, but the potent AHR agonist, TCDD, does not induce FMO3 mRNA in Hepa-1 cells. Mechanism of FMO3 mRNA induction, overview up

General Information

General Information Comment Organism
additional information chromatin immunoprecipitation assays do not detect recruitment of aryl hydrocarbon receptor or ARNT to Fmo3 regulatory elements after exposure to 3-methylcholanthrene in liver or in Hepa-1 cells. However, in Hepa-1, 3-methylcholanthrene and benzo[a]pyrene , but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, cause recruitment of p53 protein to a p53 response element in the 5'-flanking region of the Fmo3 gene. Although FMO3 mRNA is highly induced by 3-methylcholanthrene or 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse liver and in Hepa-1 cells, FMO protein levels and FMO catalytic function show only modest elevation Mus musculus