Literature summary for 1.14.13.8 extracted from

Driscoll, J.P.; Aliagas, I.; Harris, J.J.; Halladay, J.S.; Khatib-Shahidi, S.; Deese, A.; Segraves, N.; Khojasteh-Bakht, S.C.
Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination (2010), Chem. Res. Toxicol., 23, 861-863.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	recombinant FMO1	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	FMO1 mediates the formation of a reactive intermediate of 4-fluoro-N-methylaniline. FMO1 catalyzes a carbon oxidation reaction coupled with defluorination that leads to the formation of 4-N-methylaminophenol, mechanism, overview. A labile 1-fluoro-4-(methylimino)cyclohexa-2,5-dienol intermediate is formed leading to an electrophilic quinoneimine intermediate	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
flavin-containing monooxygenase 1	-	Homo sapiens
FMO1	-	Homo sapiens

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Release 2023.1 (January 2023)