Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.13.8 extracted from

  • Lee, S.K.; Kang, M.J.; Jin, C.; In, M.K.; Kim, D.H.; Yoo, H.H.
    Flavin-containing monooxygenase 1-catalysed N,N-dimethylamphetamine N-oxidation (2009), Xenobiotica, 39, 680-686.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
imipramine a FMO1-specific inhibitor, selectively inhibits N,N-dimethylamphetamine N-oxidation Homo sapiens
Methimazole inhibits N,N-dimethylamphetamine N-oxidation Homo sapiens
trimethylamine a FMO3-specific inhibitor, exhibits anegligible effect on the N,N-dimethylamphetamine N-oxide formation Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Michaelis–Menten kinetics Homo sapiens
0.0445
-
N,N-dimethylamphetamine pH 7.4, 37°C, FMO1 Homo sapiens
0.261
-
N,N-dimethylamphetamine pH 7.4, 37°C, FMO3 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N,N-dimethylamphetamine + NADPH + H+ + O2 Homo sapiens N-oxygenation mainly by isozyme FMO1, low activity with isozyme FMO3 N,N-dimethylamphetamine N-oxide + NADP+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q01740 FMO1
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N,N-dimethylamphetamine + NADPH + H+ + O2 N-oxygenation mainly by isozyme FMO1, low activity with isozyme FMO3 Homo sapiens N,N-dimethylamphetamine N-oxide + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
FMO1
-
Homo sapiens
FMO3
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
90 s, inactivation of FMO in liver microsomes Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens