Inhibitors | Comment | Organism | Structure |
---|---|---|---|
imipramine | a FMO1-specific inhibitor, selectively inhibits N,N-dimethylamphetamine N-oxidation | Homo sapiens | |
Methimazole | inhibits N,N-dimethylamphetamine N-oxidation | Homo sapiens | |
trimethylamine | a FMO3-specific inhibitor, exhibits anegligible effect on the N,N-dimethylamphetamine N-oxide formation | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | MichaelisMenten kinetics | Homo sapiens | |
0.0445 | - |
N,N-dimethylamphetamine | pH 7.4, 37°C, FMO1 | Homo sapiens | |
0.261 | - |
N,N-dimethylamphetamine | pH 7.4, 37°C, FMO3 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N,N-dimethylamphetamine + NADPH + H+ + O2 | Homo sapiens | N-oxygenation mainly by isozyme FMO1, low activity with isozyme FMO3 | N,N-dimethylamphetamine N-oxide + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q01740 | FMO1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N,N-dimethylamphetamine + NADPH + H+ + O2 | N-oxygenation mainly by isozyme FMO1, low activity with isozyme FMO3 | Homo sapiens | N,N-dimethylamphetamine N-oxide + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FMO1 | - |
Homo sapiens |
FMO3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | - |
90 s, inactivation of FMO in liver microsomes | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |