Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells | Homo sapiens |
expressed in Sf9 insect cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition of S-oxygenation of ethionamide by SKF-525A | Homo sapiens | |
additional information | lack of inhibition of S-oxygenation of ethionamide by SKF-525A | Mus musculus | |
Thiourea | inhibits S-oxygenation of ethionamide | Homo sapiens | |
Thiourea | inhibits S-oxygenation of ethionamide; thiourea reduces ethionamide oxygenation to ethionamide S-oxide by an average of 73.5% in liver and 76.9% in lung; thiourea reduces ethionamide oxygenation to ethionamide S-oxide by an average of 73.5% in liver and 76.9% in lung | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.104 | - |
Ethionamide | 37°C, isozyme FMO1 | Mus musculus | |
0.104 | - |
Ethionamide | isozyme FMO1, at pH 9.5 and 37°C | Mus musculus | |
0.105 | - |
Ethionamide | 37°C, isozyme FMO1 | Homo sapiens | |
0.105 | - |
Ethionamide | isozyme FMO1, at pH 9.5 and 37°C | Homo sapiens | |
0.114 | - |
Ethionamide | 37°C, isozyme FMO3 | Mus musculus | |
0.261 | - |
Ethionamide | 37°C, isozyme FMO2 | Homo sapiens | |
0.261 | - |
Ethionamide | isozyme FMO2, at pH 9.5 and 37°C | Homo sapiens | |
0.336 | - |
Ethionamide | 37°C, isozyme FMO3 | Homo sapiens | |
2.131 | - |
Ethionamide | 37°C, isozyme FMO2 | Mus musculus | |
2.131 | - |
Ethionamide | isozyme FMO2, at pH 9.5 and 37°C | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ethionamide + NADPH + H+ + O2 | Mus musculus | ethionamide is a pro-drug requiring bioactivation to exert toxicity | ethionamide S-oxide + NADP+ + H2O | - |
? | |
ethionamide + NADPH + H+ + O2 | Homo sapiens | ethionamide is a pro-drug requiring bioactivation to exert toxicity | ethionamide S-oxide + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q01740 | - |
- |
Homo sapiens | Q99518 | - |
- |
Mus musculus | - |
Swiss/Webster mice | - |
Mus musculus | P50285 | - |
- |
Mus musculus | Q8K2I3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | in human fetal liver, the major isozyme is FMO1 | Homo sapiens | - |
lung | - |
Mus musculus | - |
lung | - |
Homo sapiens | - |
lung | isozyme FMO2 is expressed at high levels in lung | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ethionamide + NADPH + H+ + O2 | - |
Homo sapiens | ethionamide S-oxide + NADP+ + H2O | - |
? | |
ethionamide + NADPH + H+ + O2 | - |
Mus musculus | ethionamide S-oxide + NADP+ + H2O | - |
? | |
ethionamide + NADPH + H+ + O2 | ethionamide is a pro-drug requiring bioactivation to exert toxicity | Mus musculus | ethionamide S-oxide + NADP+ + H2O | - |
? | |
ethionamide + NADPH + H+ + O2 | ethionamide is a pro-drug requiring bioactivation to exert toxicity | Homo sapiens | ethionamide S-oxide + NADP+ + H2O | - |
? | |
ethionamide + NADPH + H+ + O2 | i.e. ETA, S-oxygenation by isozymes FMO1, FMO2, and FMO3 | Mus musculus | ethionamide S-oxide + NADP+ + H2O | - |
? | |
ethionamide + NADPH + H+ + O2 | i.e. ETA, S-oxygenation by isozymes FMO1, FMO2, and FMO3 | Homo sapiens | ethionamide S-oxide + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
flavin-containing monooxygenase | - |
Homo sapiens |
flavin-containing monooxygenase | - |
Mus musculus |
FMO1 | - |
Mus musculus |
FMO1 | - |
Homo sapiens |
FMO1 | isozyme | Homo sapiens |
FMO1 | isozyme | Mus musculus |
FMO2 | - |
Mus musculus |
FMO2 | - |
Homo sapiens |
FMO2 | isozyme | Homo sapiens |
FMO2 | isozyme | Mus musculus |
FMO3 | - |
Mus musculus |
FMO3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.805 | - |
Ethionamide | 37°C, isozyme FMO2 | Homo sapiens | |
0.805 | - |
Ethionamide | isozyme FMO2, at pH 9.5 and 37°C | Homo sapiens | |
0.973 | - |
Ethionamide | 37°C, isozyme FMO3 | Homo sapiens | |
1.01 | - |
Ethionamide | 37°C, isozyme FMO3 | Mus musculus | |
1.5 | - |
Ethionamide | 37°C, isozyme FMO1 | Homo sapiens | |
1.5 | - |
Ethionamide | isozyme FMO1, at pH 9.5 and 37°C | Homo sapiens | |
4.52 | - |
Ethionamide | 37°C, isozyme FMO1 | Mus musculus | |
4.52 | - |
Ethionamide | isozyme FMO1, at pH 9.5 and 37°C | Mus musculus | |
9.45 | - |
Ethionamide | 37°C, isozyme FMO2 | Mus musculus | |
9.45 | - |
Ethionamide | isozyme FMO2, at pH 9.5 and 37°C | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Mus musculus | |
FAD | - |
Homo sapiens | |
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens | |
NADPH | required for activity | Homo sapiens | |
NADPH | required for activity | Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in metabolism of the anti-tuberculosis drug ethionamide in lung and liver, overview | Mus musculus |
metabolism | the enzyme is involved in metabolism of the anti-tuberculosis drug ethionamide in lung and liver, overview | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0028 | - |
Ethionamide | 37°C, isozyme FMO3 | Homo sapiens | |
0.0032 | - |
Ethionamide | 37°C, isozyme FMO2 | Homo sapiens | |
0.0035 | - |
Ethionamide | 37°C, isozyme FMO2 | Mus musculus | |
0.0088 | - |
Ethionamide | 37°C, isozyme FMO3 | Mus musculus | |
0.014 | - |
Ethionamide | 37°C, isozyme FMO1 | Homo sapiens | |
0.044 | - |
Ethionamide | 37°C, isozyme FMO1 | Mus musculus |