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Literature summary for 1.14.13.8 extracted from

  • Furnes, B.; Schlenk, D.
    Extrahepatic metabolism of carbamate and organophosphate thioether compounds by the flavin-containing monooxygenase and cytochrome P450 systems (2005), Drug Metab. Dispos., 33, 214-218.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
demeton-O pH 9.0, isozyme FMO1 Homo sapiens
0.079
-
methiocarb pH 9.0, isozyme FMO1 Homo sapiens
0.101
-
ethiofencarb pH 9.0, isozyme FMO1 Homo sapiens
0.25
-
demeton-O pH 9.0, isozyme FMO3 Homo sapiens
1.45
-
ethiofencarb pH 9.0, isozyme FMO3 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
demeton-O + NADPH + O2 Homo sapiens
-
demeton-O sulfoxide + NADP+ + H2O
-
?
ethiofencarb + NADPH + O2 Homo sapiens
-
ethiofencarb sulfoxide + NADP+ + H2O
-
?
fenthion + NADPH + O2 Homo sapiens
-
fenthion sulfoxide + NADP+ + H2O
-
?
methiocarb + NADPH + O2 Homo sapiens
-
methiocarb sulfoxide + NADP+ + H2O
-
?
additional information Homo sapiens FMOs are, together with cytochrome P450 monooxygenases, the major oxidative enzymes in phase I metabolism, extrahepatic metabolism of carbamate and organophosphate thioether compounds, isozyme FMO1 shows higher turnover numbers than isozyme FMO3 for all pesticides studies, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes FMO1 and FMO3
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
small intestine
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
substrate specificities of isozymes, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
demeton-O + NADPH + O2
-
Homo sapiens demeton-O sulfoxide + NADP+ + H2O
-
?
demeton-O + NADPH + O2 i.e. O,O-diethyl O-2-ethylthioethyl phosphorothioate, isozymes FMO1 and FMO3, higher activity by FMO1 Homo sapiens demeton-O sulfoxide + NADP+ + H2O
-
?
ethiofencarb + NADPH + O2
-
Homo sapiens ethiofencarb sulfoxide + NADP+ + H2O
-
?
ethiofencarb + NADPH + O2 i.e. alpha-ethylthio-o-tolyl methylcarbamate, isozymes FMO1 and FMO3, higher activity by FMO1 Homo sapiens ethiofencarb sulfoxide + NADP+ + H2O
-
?
fenthion + NADPH + O2
-
Homo sapiens fenthion sulfoxide + NADP+ + H2O
-
?
fenthion + NADPH + O2 i.e. O,O-dimethyl O-4-methylthio-m-tolyl phosphorothioate, isozymes FMO1 and FMO3, stereospecifc product formation, overview Homo sapiens fenthion sulfoxide + NADP+ + H2O
-
?
methiocarb + NADPH + O2
-
Homo sapiens methiocarb sulfoxide + NADP+ + H2O
-
?
methiocarb + NADPH + O2 i.e. 4-methylthio-3,5-xylyl methylcarbamate, isozyme FMO1 acts stereospecifically, no activity by isozyme FMO3 Homo sapiens methiocarb sulfoxide + NADP+ + H2O
-
?
additional information FMOs are, together with cytochrome P450 monooxygenases, the major oxidative enzymes in phase I metabolism, extrahepatic metabolism of carbamate and organophosphate thioether compounds, isozyme FMO1 shows higher turnover numbers than isozyme FMO3 for all pesticides studies, overview Homo sapiens ?
-
?
additional information carbophenothion, i.e. S-4-chlorophenylthiomethyl O,O-diethyl phosphorodithioate, and fonofos, i.e. O-ethyl S-phenyl (RS)-ethylphosphonodithioate, are poor substrates Homo sapiens ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4 9 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
NADPH
-
Homo sapiens