KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.013 | - |
demeton-O | pH 9.0, isozyme FMO1 | Homo sapiens | |
0.079 | - |
methiocarb | pH 9.0, isozyme FMO1 | Homo sapiens | |
0.101 | - |
ethiofencarb | pH 9.0, isozyme FMO1 | Homo sapiens | |
0.25 | - |
demeton-O | pH 9.0, isozyme FMO3 | Homo sapiens | |
1.45 | - |
ethiofencarb | pH 9.0, isozyme FMO3 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
demeton-O + NADPH + O2 | Homo sapiens | - |
demeton-O sulfoxide + NADP+ + H2O | - |
? | |
ethiofencarb + NADPH + O2 | Homo sapiens | - |
ethiofencarb sulfoxide + NADP+ + H2O | - |
? | |
fenthion + NADPH + O2 | Homo sapiens | - |
fenthion sulfoxide + NADP+ + H2O | - |
? | |
methiocarb + NADPH + O2 | Homo sapiens | - |
methiocarb sulfoxide + NADP+ + H2O | - |
? | |
additional information | Homo sapiens | FMOs are, together with cytochrome P450 monooxygenases, the major oxidative enzymes in phase I metabolism, extrahepatic metabolism of carbamate and organophosphate thioether compounds, isozyme FMO1 shows higher turnover numbers than isozyme FMO3 for all pesticides studies, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes FMO1 and FMO3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
substrate specificities of isozymes, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
demeton-O + NADPH + O2 | - |
Homo sapiens | demeton-O sulfoxide + NADP+ + H2O | - |
? | |
demeton-O + NADPH + O2 | i.e. O,O-diethyl O-2-ethylthioethyl phosphorothioate, isozymes FMO1 and FMO3, higher activity by FMO1 | Homo sapiens | demeton-O sulfoxide + NADP+ + H2O | - |
? | |
ethiofencarb + NADPH + O2 | - |
Homo sapiens | ethiofencarb sulfoxide + NADP+ + H2O | - |
? | |
ethiofencarb + NADPH + O2 | i.e. alpha-ethylthio-o-tolyl methylcarbamate, isozymes FMO1 and FMO3, higher activity by FMO1 | Homo sapiens | ethiofencarb sulfoxide + NADP+ + H2O | - |
? | |
fenthion + NADPH + O2 | - |
Homo sapiens | fenthion sulfoxide + NADP+ + H2O | - |
? | |
fenthion + NADPH + O2 | i.e. O,O-dimethyl O-4-methylthio-m-tolyl phosphorothioate, isozymes FMO1 and FMO3, stereospecifc product formation, overview | Homo sapiens | fenthion sulfoxide + NADP+ + H2O | - |
? | |
methiocarb + NADPH + O2 | - |
Homo sapiens | methiocarb sulfoxide + NADP+ + H2O | - |
? | |
methiocarb + NADPH + O2 | i.e. 4-methylthio-3,5-xylyl methylcarbamate, isozyme FMO1 acts stereospecifically, no activity by isozyme FMO3 | Homo sapiens | methiocarb sulfoxide + NADP+ + H2O | - |
? | |
additional information | FMOs are, together with cytochrome P450 monooxygenases, the major oxidative enzymes in phase I metabolism, extrahepatic metabolism of carbamate and organophosphate thioether compounds, isozyme FMO1 shows higher turnover numbers than isozyme FMO3 for all pesticides studies, overview | Homo sapiens | ? | - |
? | |
additional information | carbophenothion, i.e. S-4-chlorophenylthiomethyl O,O-diethyl phosphorodithioate, and fonofos, i.e. O-ethyl S-phenyl (RS)-ethylphosphonodithioate, are poor substrates | Homo sapiens | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | 9 | assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |