Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.13.8 extracted from

  • Tsutsumi, H.; Katagi, M.; Nishikawa, M.; Tsuchihashi, H.; Kasuya, F.; Igarashi, K.
    In vitro confirmation of selegiline N-oxidation by flavin-containing monooxygenase in rat microsome using LC-ESI MS (2004), Biol. Pharm. Bull., 27, 1572-1575.
    View publication on PubMed
Search for more literature for 1.14.13.8

Activating Compound

Activating Compound Comment Organism Structure
n-octylamine 1 mM, 2fold stimulation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Methimazole
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0713
-
 selegiline pH 8.0 Rattus norvegicus
0.1775
-
 selegiline pH 7.4 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
selegiline + NADPH + O2 Rattus norvegicus
-
 selegiline N-oxide + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
selegiline + NADPH + O2
-
 Rattus norvegicus selegiline N-oxide + NADP+
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 8.5
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus