KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
N,N-Dimethylaniline | - |
Sus scrofa | |
0.03 | - |
N-Aminopiperidine | - |
Sus scrofa | |
0.08 | - |
1-Methyl-1-phenylhydrazine | - |
Sus scrofa | |
0.1 | - |
N-aminopyrrolidine | - |
Sus scrofa | |
0.17 | - |
N-Aminohomopiperidine | - |
Sus scrofa | |
0.38 | - |
1,1-Dimethylhydrazine | - |
Sus scrofa | |
0.61 | - |
N-aminomorpholine | - |
Sus scrofa | |
2 | - |
1-methyl-2-benzylhydrazine | - |
Sus scrofa | |
3 | - |
phenylhydrazine | - |
Sus scrofa | |
3.3 | - |
beta-ethylphenylhydrazine | - |
Sus scrofa | |
5.7 | - |
procarbazine | - |
Sus scrofa | |
6.9 | - |
butylhydrazine | - |
Sus scrofa | |
7 | - |
benzylhydrazine | - |
Sus scrofa | |
8.3 | - |
isopropylhydrazine | - |
Sus scrofa | |
12 | - |
1,2-dimethylhydrazine | - |
Sus scrofa | |
15 | - |
n-propylhydrazine | - |
Sus scrofa | |
35 | - |
methylhydrazine | - |
Sus scrofa | |
40 | - |
ethylhydrazine | - |
Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,1-dimethylhydrazine + NADPH + O2 | Rattus norvegicus | possibly, and other 1,1-disubstituted hydrazines | formaldehyde + CH3N2H3 + NADP+ | - |
? | |
1,1-dimethylhydrazine + NADPH + O2 | Sus scrofa | possibly, and other 1,1-disubstituted hydrazines | formaldehyde + CH3N2H3 + NADP+ | - |
? | |
1,1-dimethylhydrazine + NADPH + O2 | Mesocricetus auratus | possibly, and other 1,1-disubstituted hydrazines | formaldehyde + CH3N2H3 + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mesocricetus auratus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
liver | - |
Mesocricetus auratus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,1-dimethylhydrazine + NADPH + O2 | - |
Rattus norvegicus | formaldehyde + CH3N2H3 + NADP+ | - |
? | |
1,1-dimethylhydrazine + NADPH + O2 | - |
Sus scrofa | formaldehyde + CH3N2H3 + NADP+ | - |
? | |
1,1-dimethylhydrazine + NADPH + O2 | - |
Mesocricetus auratus | formaldehyde + CH3N2H3 + NADP+ | - |
? | |
1,1-dimethylhydrazine + NADPH + O2 | possibly, and other 1,1-disubstituted hydrazines | Rattus norvegicus | formaldehyde + CH3N2H3 + NADP+ | - |
? | |
1,1-dimethylhydrazine + NADPH + O2 | possibly, and other 1,1-disubstituted hydrazines | Sus scrofa | formaldehyde + CH3N2H3 + NADP+ | - |
? | |
1,1-dimethylhydrazine + NADPH + O2 | possibly, and other 1,1-disubstituted hydrazines | Mesocricetus auratus | formaldehyde + CH3N2H3 + NADP+ | - |
? | |
1,2-dimethylhydrazine + NADPH + H+ + O2 | - |
Sus scrofa | 1,2-dimethylhydrazine N-oxide + NADP+ + H2O | - |
r | |
1,2-dimethylhydrazine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
1,2-dimethylhydrazine + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? | |
1,2-dimethylphenylhydrazine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
1,2-dimethylphenylhydrazine + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? | |
1-methyl-1-phenylhydrazine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
1-methyl-1-phenylhydrazine + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
1-methyl-1-phenylhydrazine + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? | |
1-methyl-2-benzylhydrazine + NADPH + H+ + O2 | - |
Sus scrofa | 1-methyl-2-benzylhydrazine N-oxide + NADP+ + H2O | - |
r | |
1-methyl-2-benzylhydrazine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
1-methyl-2-benzylhydrazine + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? | |
benzylhydrazine + NADPH + H+ + O2 | - |
Sus scrofa | benzylhydrazine N-oxide + NADP+ + H2O | - |
r | |
benzylhydrazine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
benzylhydrazine + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? | |
beta-ethylphenylhydrazine + NADPH + H+ + O2 | - |
Sus scrofa | beta-ethylphenylhydrazine N-oxide + NADP+ + H2O | - |
r | |
beta-ethylphenylhydrazine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
beta-ethylphenylhydrazine + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? | |
butylhydrazine + NADPH + H+ + O2 | - |
Sus scrofa | butylhydrazine N-oxide + NADP+ + H2O | - |
r | |
butylhydrazine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
butylhydrazine + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? | |
ethylhydrazine + NADPH + H+ + O2 | - |
Sus scrofa | ethylhydrazine N-oxide + NADP+ + H2O | - |
r | |
isopropylhydrazine + NADPH + H+ + O2 | - |
Sus scrofa | isopropylhydrazine N-oxide + NADP+ + H2O | - |
r | |
isopropylhydrazine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
isopropylhydrazine + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? | |
N,N-dimethylaniline + NADPH + H+ + O2 | - |
Sus scrofa | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
r | |
N,N-dimethylaniline + NADPH + O2 | - |
Rattus norvegicus | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
N,N-dimethylaniline + NADPH + O2 | - |
Sus scrofa | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
N,N-dimethylaniline + NADPH + O2 | - |
Mesocricetus auratus | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
N-aminohomopiperidine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
N-aminohomopiperidine + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
N-aminohomopiperidine + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? | |
N-aminomorpholine + NADPH + H+ + O2 | - |
Sus scrofa | N-aminomorpholine N-oxide + NADP+ + H2O | - |
r | |
N-aminomorpholine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
N-aminomorpholine + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? | |
N-aminopiperidine + NADPH + O2 | - |
Rattus norvegicus | tetrazene + NADP+ + H2O + ? | - |
? | |
N-aminopiperidine + NADPH + O2 | - |
Sus scrofa | tetrazene + NADP+ + H2O + ? | - |
? | |
N-aminopiperidine + NADPH + O2 | - |
Mesocricetus auratus | tetrazene + NADP+ + H2O + ? | - |
? | |
N-aminopiperidine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
N-aminopiperidine + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? | |
N-aminopyrrolidine + NADPH + H+ + O2 | - |
Sus scrofa | N-aminopyrrolidine N-oxide + NADP+ + H2O | - |
r | |
N-aminopyrrolidone + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
N-aminopyrrolidone + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? | |
n-propylhydrazine + NADPH + H+ + O2 | - |
Sus scrofa | N-propylhydrazine N-oxide + NADP+ + H2O | - |
r | |
phenylhydrazine + NADPH + H+ + O2 | - |
Sus scrofa | phenylhydrazine N-oxide + NADP+ + H2O | - |
r | |
phenylhydrazine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
phenylhydrazine + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? | |
procarbazine + NADPH + H+ + O2 | - |
Sus scrofa | procarbazine N-oxide + NADP+ + H2O | - |
r | |
procarbazine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
procarbazine + NADPH + O2 | - |
Mesocricetus auratus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.4 | - |
demethylation of 1,1-dimethylhydrazine | Mesocricetus auratus |
8.5 | - |
hydrazine oxidation | Sus scrofa |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.5 | 9 | pH 7.5: about 40% of activity maximum, pH 9.0: about 95% of activity maximum | Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | flavoprotein | Rattus norvegicus | |
FAD | flavoprotein | Sus scrofa | |
FAD | flavoprotein | Mesocricetus auratus | |
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Sus scrofa | |
NADPH | - |
Mesocricetus auratus |