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Literature summary for 1.14.13.39 extracted from

  • Freire, M.A.M.; Lima, R.R.; Nascimento, P.C.; Gomes-Leal, W.; Pereira, A.
    Effects of methylmercury on the pattern of NADPH diaphorase expression and astrocytic activation in the rat (2020), Ecotoxicol. Environ. Saf., 201, 110799 .
    View publication on PubMed
Search for more literature for 1.14.13.39

Inhibitors

Inhibitors Comment Organism Structure
MeHg methylmercury, impact of chronic MeHg intoxication on NADPH diaphorase (NADPH-d) activity and astrocyte mobilization in the visual cortex of the rat, overview. MeHg accumulates in the central nervous system (CNS) and preferentially accumulates in astrocytes, and it causes several neurotoxic effects, such as visual-field constriction, cerebellar ataxia and multimodal sensory disorders. MeHg-intoxicated animals display a significant decrease of NADPH-d neuropil reactivity across the visual cortex when compared to controls. The decreased neuropil reactivity to NADPH-d may also be related to MeHg-induced astrocytic dysfunction Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 Rattus norvegicus overall reaction 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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2 L-arginine + 3 NADPH + 3 H+ + 4 O2 Rattus norvegicus Wistar overall reaction 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus P29476
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Rattus norvegicus Wistar P29476
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
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 Rattus norvegicus
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brain visual cortex, use of the NADPH-d histochemistry technique to evaluate the expression of NOS across the nervous system Rattus norvegicus
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additional information pattern of NADPH-d neuropil staining and pattern of astrocyte reactivity, qualitative and quantitative analysis, overview. MeHg-intoxicated animals display a significant decrease of NADPH-d neuropil reactivity across the visual cortex when compared to controls Rattus norvegicus
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neuron the NADPH-d histochemistry stains a selective population of neurons in the brain. The staining allows the visualization of the dendritic tree, resembling a Golgi impregnation, and the cells are distributed sparsely in the cortical tissue, allowing their unbiased identification and reconstruction, quantitative analysis, overview Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 overall reaction Rattus norvegicus 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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 ?
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 overall reaction Rattus norvegicus Wistar 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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 ?

Synonyms

Synonyms Comment Organism
NADPH diaphorase
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 Rattus norvegicus
NADPH-d
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 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH provided from the nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH diaphorase) activity. In the brain, NADPH diaphorase (NADPH-d) and nNOS are strictly co-localized Rattus norvegicus

General Information

General Information Comment Organism
physiological function nitric oxide (NO) is a ubiquitous gaseous cellular messenger with multiple physiological roles in the brain, such as synaptic plasticity, neurotransmission, neuronal communication, neurogenesis, learning, and memory. NO can be generated by three different isoforms of the enzyme nitric oxide synthase (NOS): neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS), from L-arginine as the substrate and molecular oxygen and NADPH as cosubstrates Rattus norvegicus