Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.13.39 extracted from

  • Brindicci, C.; Kharitonov, S.A.; Ito, M.; Elliott, M.W.; Hogg, J.C.; Barnes, P.J.; Ito, K.
    Nitric oxide synthase isoenzyme expression and activity in peripheral lungs of COPD patients (2009), Am. J. Respir. Crit. Care Med., 181, 21-30.
    View publication on PubMed
Search for more literature for 1.14.13.39

Organism

Organism UniProt Comment Textmining
Homo sapiens P29474
-
-
Homo sapiens P29475
-
-
Homo sapiens P35228
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
lung
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
nitric oxide synthase
-
 Homo sapiens
NO synthase type I nNOS Homo sapiens
NO synthase type II iNOS Homo sapiens
NO synthase type III eNOS Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of eNOS mRNA and protein does not change in mild to moderate chronic obstructive pulmonary disease, but is reduced in the more severe stages of chronic obstructive pulmonary disease down
Homo sapiens in the peripheral lung of chronic obstructive pulmonary disease patients iNOS mRNA expression is increased at earlier stages of the disease but decreases in the most severe patients, pro-inflammatory cytokine-induced iNOS expression is decreased by oxidative stress, such as H2O2, cigarette smoke conditioned media, and the peroxyntrite generator SIN1 up
Homo sapiens lung tissue from patients with severe and very severe chronic obstructive pulmonary disease have graded increases in nNOS (mRNA and protein) compared with non-smokers and normal smokers up