Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | iNOS is induced by pathogens and their components, e.g. induction in alveolar macropages by infection with the intracellular pathogen Mycobacterium bovis | Bos taurus |
Cloned (Comment) | Organism |
---|---|
iNOS, DNA and amino acid sequence determination and analysis, phylogenetic analysis | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 | Bos taurus | NO is an important signalling molecule, released by numerous cells, that acts in many tissues to regulate a diverse range of physiological and biological processes, including neurotransmission, immune defence and the regulation of apoptosis. NO plays a major role in the killing of intracellular pathogens as part of the innate immune response | 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | Q9BDQ7 | fragment of iNOS | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | alveolar | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 | - |
Bos taurus | 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | - |
? | |
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 | NO is an important signalling molecule, released by numerous cells, that acts in many tissues to regulate a diverse range of physiological and biological processes, including neurotransmission, immune defence and the regulation of apoptosis. NO plays a major role in the killing of intracellular pathogens as part of the innate immune response | Bos taurus | 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | iNOS domain structure, overview | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
inducible nitric oxide synthase | - |
Bos taurus |
iNOS | - |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | binding site sequence, overview | Bos taurus | |
flavodoxin I | binding site sequence, overview | Bos taurus | |
NADPH | binding site sequence, overview | Bos taurus |