Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.13.39 extracted from

  • Reif, D.W.; McCreedy, S.A.
    N-Nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases (1995), Arch. Biochem. Biophys., 320, 170-176.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol
-
Mus musculus
dithiothreitol
-
Homo sapiens
dithiothreitol
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Ngamma-monomethyl-L-arginine endothelial and neuronal isoforms: reversible inhibition; L-arginine protects against enzyme inactivation, thus inactivation occurs at or near active site Homo sapiens
Ngamma-monomethyl-L-arginine inducible isoform: after preincubation irreversible, time- and concentration-dependent inactivation, without preincubation reversible inhibition; L-arginine protects against enzyme inactivation, thus inactivation occurs at or near active site Mus musculus
Ngamma-monomethyl-L-arginine endothelial and neuronal isoforms: reversible inhibition; in presence of tetrahydrobiopterin 0.004 mM the neuronal isoform is inactivated; L-arginine protects against enzyme inactivation, thus inactivation occurs at or near active site Rattus norvegicus
Ngamma-nitro-L-arginine irreversible inactivation of neuronal and endothelial isoform after preincubation, unaffected by tetrahydrobiopterin; L-arginine protects against enzyme inactivation, thus inactivation occurs at or near active site Homo sapiens
Ngamma-nitro-L-arginine L-arginine protects against enzyme inactivation, thus inactivation occurs at or near active site; reversible inhibitor of inducible isoform from macrophage Mus musculus
Ngamma-nitro-L-arginine irreversible inactivation of neuronal and endothelial isoform after preincubation, unaffected by tetrahydrobiopterin; L-arginine protects against enzyme inactivation, thus inactivation occurs at or near active site Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
cytosol
-
Homo sapiens 5829
-
cytosol
-
Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Mus musculus
Ca2+
-
Homo sapiens
Ca2+
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
Sprague-Dawley
-
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
cerebellum
-
Homo sapiens
-
cerebellum
-
Rattus norvegicus
-
endothelium
-
Mus musculus
-
endothelium
-
Rattus norvegicus
-
endothelium umbilical vein cells Homo sapiens
-
macrophage
-
Homo sapiens
-
macrophage
-
Rattus norvegicus
-
macrophage RAW 264.7 cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Mus musculus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Homo sapiens 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Rattus norvegicus Sprague-Dawley 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?

Synonyms

Synonyms Comment Organism
e-NOS endothelial isoform III Homo sapiens
i-NOS isoform II, inducible Mus musculus
i-NOS isoform II, inducible Homo sapiens
i-NOS isoform II, inducible Rattus norvegicus
n-NOS isoform I, neuronal enzyme Homo sapiens
n-NOS isoform I, neuronal enzyme Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus
37
-
assay at Homo sapiens
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus
7.4
-
assay at Homo sapiens
7.4
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
5,6,7,8-tetrahydro-L-biopterin
-
Mus musculus
5,6,7,8-tetrahydro-L-biopterin
-
Homo sapiens
5,6,7,8-tetrahydro-L-biopterin
-
Rattus norvegicus
Calmodulin
-
Mus musculus
Calmodulin
-
Homo sapiens
Calmodulin
-
Rattus norvegicus
NADPH
-
Mus musculus
NADPH
-
Homo sapiens
NADPH
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00002
-
Ngamma-nitro-L-arginine irreversible inactivation of endothelial isoform after preincubation Homo sapiens
0.00009
-
Ngamma-nitro-L-arginine irreversible inactivation of neuronal isoform after preincubation Rattus norvegicus
0.0007
-
Ngamma-monomethyl-L-arginine
-
Rattus norvegicus
0.0007
-
Ngamma-monomethyl-L-arginine endothelial isoform Homo sapiens
0.002
-
Ngamma-monomethyl-L-arginine neuronal isoform in presence of 0.004 mM tetrahydrobiopterin Rattus norvegicus
0.0026
-
Ngamma-monomethyl-L-arginine inducible isoform from macrophage after preincubation Mus musculus
0.0039
-
Ngamma-monomethyl-L-arginine inducible isoform from macrophage without preincubation Mus musculus
0.0065
-
Ngamma-monomethyl-L-arginine neuronal isoform Rattus norvegicus
0.0081
-
Ngamma-nitro-L-arginine reversible inhibition of inducible macrophage isoform Mus musculus