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Literature summary for 1.14.13.39 extracted from

  • Sheng, H.; Ignarro, L.J.
    Biochemical and immunohistochemical characterization of nitric oxide synthase in the rat retina (1996), Pharm. Res., 33, 29-34.
    View publication on PubMed
Search for more literature for 1.14.13.39

Inhibitors

Inhibitors Comment Organism Structure
Calmidazolium in absence of calmodulin Rattus norvegicus
Trifluoperazine in absence of calmodulin Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ cerebellum enzyme is Ca2+-dependent Rattus norvegicus
Ca2+ retina enzyme is dependent on Ca2+ Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar strain
-
Rattus norvegicus Wistar
-
 Wistar strain
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cerebellum
-
 Rattus norvegicus
-
additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Rattus norvegicus
-
retina constitutive, soluble form Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Rattus norvegicus Wistar 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus