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Literature summary for 1.14.13.39 extracted from

  • Cote, J.F.; Roberge, A.G.
    Nitric oxide synthase in cat brain: cofactors - enzyme-substrate interaction (1996), Free Radic. Biol. Med., 21, 109-115.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
EDTA brain enzyme Felis catus
ethylene glycol bis(beta-amino-ethylether)-N,N,N',N'-tetraacetic acid
-
Felis catus
N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide calmodulin antagonist above 0.01 mM; i.e. W-7 Felis catus
Ngamma-monomethyl-L-arginine
-
Felis catus
Ngamma-nitro-L-arginine
-
Felis catus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
L-arginine with FAD and tetrahydropterin Felis catus
0.041
-
L-arginine without tetrahydropterin and FAD Felis catus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Felis catus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required, calmodulin independent Felis catus

Organism

Organism UniProt Comment Textmining
Felis catus
-
mongrel cat
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Felis catus
-
cerebral cortex
-
Felis catus
-
hippocampus
-
Felis catus
-
hypothalamus
-
Felis catus
-
mesencephalon
-
Felis catus
-
neostriatum
-
Felis catus
-
pons
-
Felis catus
-
thalamus
-
Felis catus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Felis catus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Felis catus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Felis catus

pH Range

pH Minimum pH Maximum Comment Organism
6.6 8
-
Felis catus

Cofactor

Cofactor Comment Organism Structure
5,6,7,8-tetrahydro-L-biopterin required Felis catus
Calmodulin required Felis catus
FAD
-
Felis catus
FMN
-
Felis catus
NADPH dependent on Felis catus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000041
-
Ngamma-nitro-L-arginine
-
Felis catus
0.00031
-
Ngamma-monomethyl-L-arginine
-
Felis catus