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Literature summary for 1.14.13.35 extracted from

  • Rao, P.V.S.; Sreeleela, N.S.; Premakumar, R.; Vaidyanathan, C.S.
    Regulation of the pathway for the degradation of anthranilate in Aspergillus niger (1971), J. Bacteriol., 107, 100-105.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
3-Hydroxyanthranilate induces Aspergillus niger
anthranilate induces, the enzyme activity increases with an increase in the concentration of anthranilate in the growth medium, optimal amounts of the enzyme are synthesized when the concentration of anthranilate is 1 mg/ml, further increase in the concentration results in a considerable decrease in the growth of the organism as well in the enzyme activity Aspergillus niger
kynurenine induces Aspergillus niger
L-tryptophan induces Aspergillus niger

Inhibitors

Inhibitors Comment Organism Structure
cycloheximide inhibits the enzyme induction Aspergillus niger

Organism

Organism UniProt Comment Textmining
Aspergillus niger
-
inducible enzyme
-
Aspergillus niger
-
UBC 814
-
Aspergillus niger UBC 814
-
UBC 814
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0026
-
organism grown on the standard medium with kynurenine Aspergillus niger
0.0032
-
organism grown on the standard medium with tryptophan Aspergillus niger
0.0056
-
organism grown on the standard medium with 3-hydroxyanthranilate Aspergillus niger
0.0058
-
organism grown on the standard medium with anthranilate Aspergillus niger

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anthranilate + NADPH + O2
-
Aspergillus niger 2,3-dihydroxybenzoate + NADP+ + NH3
-
?
anthranilate + NADPH + O2
-
Aspergillus niger UBC 814 2,3-dihydroxybenzoate + NADP+ + NH3
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
for optimal induction Aspergillus niger
8.2
-
assay at Aspergillus niger

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Aspergillus niger